Developmental abnormalities in infants and children with acquired immune deficiency syndrome (AIDS) and AIDS-related complex

M. H. Ultmann, A. L. Belman, H. A. Ruff, B. E. Novick, B. Cone-Wesson, H. J. Cohen, Arye Rubinstein

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Abstract

Children with acquired immune deficiency syndrome (AIDS) display two types of clinical picture: (1) a full-blown AIDS characterized by the presence of opportunistic infections and/or Kaposi's sarcoma and (2) a prodromal stage now identified as AIDS-related complex (ARC). Neurological complications have been identified in infants and children with the disease. This paper discusses the developmental abnormalities in 16 pediatric patients, seven with AIDS and nine with ARC, ranging in age from six months to six years. In all cases, the mothers of these children either had ARC, AIDS and/or used intravenous drugs. Developmental histories showed delayed acquisition of milestones in most children following the diagnosis of AIDS or ARC, with delayed motor milestones consistently noted in both groups. Several children with AIDS actually lost milestones as their illness progressed; this has not occurred in the ARC group. Psychometric testing revealed more severe cognitive dysfunction in the group with AIDS. Involvement of the central nervous system was documented clinically, radiologically, and/or electrophysiologically in all patients with AIDS. In the ARC group the course of the illness has shown greater variability. Medical and social factors that may contribute to the developmental abnormalities are discussed.

Original languageEnglish (US)
Pages (from-to)563-571
Number of pages9
JournalDevelopmental Medicine and Child Neurology
Volume27
Issue number5
StatePublished - 1985

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Acquired Immunodeficiency Syndrome
AIDS-Related Complex
Prodromal Symptoms
Kaposi's Sarcoma
Opportunistic Infections
Psychometrics
Central Nervous System
Mothers
Pediatrics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)

Cite this

Developmental abnormalities in infants and children with acquired immune deficiency syndrome (AIDS) and AIDS-related complex. / Ultmann, M. H.; Belman, A. L.; Ruff, H. A.; Novick, B. E.; Cone-Wesson, B.; Cohen, H. J.; Rubinstein, Arye.

In: Developmental Medicine and Child Neurology, Vol. 27, No. 5, 1985, p. 563-571.

Research output: Contribution to journalArticle

Ultmann, M. H. ; Belman, A. L. ; Ruff, H. A. ; Novick, B. E. ; Cone-Wesson, B. ; Cohen, H. J. ; Rubinstein, Arye. / Developmental abnormalities in infants and children with acquired immune deficiency syndrome (AIDS) and AIDS-related complex. In: Developmental Medicine and Child Neurology. 1985 ; Vol. 27, No. 5. pp. 563-571.
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