Twelfth and thirteenth gestation day mouse embryo otocysts have been explanted into an organ culture system that promotes advances in morphogenesis and differentiation of sensory structures. The pattern of morphogenesis that occurs “in vitro” is not equivalent to that which occurs in the “in vivo” environment. These morphogenetic changes occur with greatest frequency in the explanted thirteenth gestation day otocyst. The development of sensory structures occurs with equal distribution in the twelfth and thirteenth gestation day explanted otocysts. The thirteenth gestation day mouse otocyst favors the development of organ of Corti type formations, and the twelfth gestation day otocyst favors the development of maculae of sensory cells of a vestibular character in the organ culture system employed. The thirteenth gestation day otocyst requires a shorter period of “in vitro” development to produce differentiation of sensory structures. The sensory structures that develop “in vitro” follow the pattern of the sensory structures that develop “in vivo.”.
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