Development of an intraluminal device for the treatment of aortic regurgitation: Prototype and in vitro testing system

Jr Ashton R.C., Daniel J. Goldstein, D. D'Alessandro, A. D. Weinberg, D. Burkhoff, H. D. Rosskothen, G. M. Lemole, M. C. Oz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Development of an intraluminal device to reduce aortic regurgitation could provide a strategy intermediate between medical treatment and aortic valve replacement. An initial prototype and a testing system have been designed. Methods: Aortic valves obtained from heart transplant recipients were explanted and assessed in a mock circulatory loop with resistive and capacitive elements, including pressure-flow characteristics, similar to those of a normal arterial system. Normal heart function was simulated by a pulsatile ventricular-assist device. Pressure on each side of the valve and flow through the valve were recorded, allowing the calculation of regurgitant fractions and transvalvular gradients. Six solid geometrically differing obturators were tested. Results: All six designs resulted in significant reduction in aortic regurgitation (p < 0.0001), ranging from 15% to 38% improvement compared with control values. Small increases in transvalvular gradients (from 0 to 7 mm Hg) were also noted. Discussion: Initial results suggest that an intraluminally placed obturator can reduce aortic regurgitation without creating clinically significant transvalvular gradients. These initial in vitro experiments demonstrate the feasibility of an intraluminal device for the treatment of aortic valve disease, and further investigation is warranted.

Original languageEnglish (US)
Pages (from-to)979-983
Number of pages5
JournalJournal of Thoracic and Cardiovascular Surgery
Volume112
Issue number4
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Aortic Valve Insufficiency
Aortic Valve
Equipment and Supplies
Pressure
Aortic Diseases
Heart-Assist Devices
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Development of an intraluminal device for the treatment of aortic regurgitation : Prototype and in vitro testing system. / Ashton R.C., Jr; Goldstein, Daniel J.; D'Alessandro, D.; Weinberg, A. D.; Burkhoff, D.; Rosskothen, H. D.; Lemole, G. M.; Oz, M. C.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 112, No. 4, 1996, p. 979-983.

Research output: Contribution to journalArticle

Ashton R.C., Jr ; Goldstein, Daniel J. ; D'Alessandro, D. ; Weinberg, A. D. ; Burkhoff, D. ; Rosskothen, H. D. ; Lemole, G. M. ; Oz, M. C. / Development of an intraluminal device for the treatment of aortic regurgitation : Prototype and in vitro testing system. In: Journal of Thoracic and Cardiovascular Surgery. 1996 ; Vol. 112, No. 4. pp. 979-983.
@article{4f435cd329b145fdba55d33b8dfed4ce,
title = "Development of an intraluminal device for the treatment of aortic regurgitation: Prototype and in vitro testing system",
abstract = "Objectives: Development of an intraluminal device to reduce aortic regurgitation could provide a strategy intermediate between medical treatment and aortic valve replacement. An initial prototype and a testing system have been designed. Methods: Aortic valves obtained from heart transplant recipients were explanted and assessed in a mock circulatory loop with resistive and capacitive elements, including pressure-flow characteristics, similar to those of a normal arterial system. Normal heart function was simulated by a pulsatile ventricular-assist device. Pressure on each side of the valve and flow through the valve were recorded, allowing the calculation of regurgitant fractions and transvalvular gradients. Six solid geometrically differing obturators were tested. Results: All six designs resulted in significant reduction in aortic regurgitation (p < 0.0001), ranging from 15{\%} to 38{\%} improvement compared with control values. Small increases in transvalvular gradients (from 0 to 7 mm Hg) were also noted. Discussion: Initial results suggest that an intraluminally placed obturator can reduce aortic regurgitation without creating clinically significant transvalvular gradients. These initial in vitro experiments demonstrate the feasibility of an intraluminal device for the treatment of aortic valve disease, and further investigation is warranted.",
author = "{Ashton R.C.}, Jr and Goldstein, {Daniel J.} and D. D'Alessandro and Weinberg, {A. D.} and D. Burkhoff and Rosskothen, {H. D.} and Lemole, {G. M.} and Oz, {M. C.}",
year = "1996",
doi = "10.1016/S0022-5223(96)70098-3",
language = "English (US)",
volume = "112",
pages = "979--983",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Development of an intraluminal device for the treatment of aortic regurgitation

T2 - Prototype and in vitro testing system

AU - Ashton R.C., Jr

AU - Goldstein, Daniel J.

AU - D'Alessandro, D.

AU - Weinberg, A. D.

AU - Burkhoff, D.

AU - Rosskothen, H. D.

AU - Lemole, G. M.

AU - Oz, M. C.

PY - 1996

Y1 - 1996

N2 - Objectives: Development of an intraluminal device to reduce aortic regurgitation could provide a strategy intermediate between medical treatment and aortic valve replacement. An initial prototype and a testing system have been designed. Methods: Aortic valves obtained from heart transplant recipients were explanted and assessed in a mock circulatory loop with resistive and capacitive elements, including pressure-flow characteristics, similar to those of a normal arterial system. Normal heart function was simulated by a pulsatile ventricular-assist device. Pressure on each side of the valve and flow through the valve were recorded, allowing the calculation of regurgitant fractions and transvalvular gradients. Six solid geometrically differing obturators were tested. Results: All six designs resulted in significant reduction in aortic regurgitation (p < 0.0001), ranging from 15% to 38% improvement compared with control values. Small increases in transvalvular gradients (from 0 to 7 mm Hg) were also noted. Discussion: Initial results suggest that an intraluminally placed obturator can reduce aortic regurgitation without creating clinically significant transvalvular gradients. These initial in vitro experiments demonstrate the feasibility of an intraluminal device for the treatment of aortic valve disease, and further investigation is warranted.

AB - Objectives: Development of an intraluminal device to reduce aortic regurgitation could provide a strategy intermediate between medical treatment and aortic valve replacement. An initial prototype and a testing system have been designed. Methods: Aortic valves obtained from heart transplant recipients were explanted and assessed in a mock circulatory loop with resistive and capacitive elements, including pressure-flow characteristics, similar to those of a normal arterial system. Normal heart function was simulated by a pulsatile ventricular-assist device. Pressure on each side of the valve and flow through the valve were recorded, allowing the calculation of regurgitant fractions and transvalvular gradients. Six solid geometrically differing obturators were tested. Results: All six designs resulted in significant reduction in aortic regurgitation (p < 0.0001), ranging from 15% to 38% improvement compared with control values. Small increases in transvalvular gradients (from 0 to 7 mm Hg) were also noted. Discussion: Initial results suggest that an intraluminally placed obturator can reduce aortic regurgitation without creating clinically significant transvalvular gradients. These initial in vitro experiments demonstrate the feasibility of an intraluminal device for the treatment of aortic valve disease, and further investigation is warranted.

UR - http://www.scopus.com/inward/record.url?scp=0029817557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029817557&partnerID=8YFLogxK

U2 - 10.1016/S0022-5223(96)70098-3

DO - 10.1016/S0022-5223(96)70098-3

M3 - Article

C2 - 8873724

AN - SCOPUS:0029817557

VL - 112

SP - 979

EP - 983

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

IS - 4

ER -