Development of a new animal model of chronic mitral regurgitation in rats under transesophageal echocardiographic guidance

Min Pu; Zhaohui Gao; Jianhua Li; Lawrence Sinoway; William R. Davidson

doi:10.1016/j.echo.2004.10.005

Development of a new animal model of chronic mitral regurgitation in rats under transesophageal echocardiographic guidance

Min Pu, Zhaohui Gao, Jianhua Li, Lawrence Sinoway, William R. Davidson

Research output: Contribution to journal › Conference article › peer-review

9 Scopus citations

Abstract

Large animal models (dog and sheep) are often used for the investigation of the pathophysiology of chronic mitral regurgitation (MR). A major limitation of large animal models is cost. The aim of this study was to develop a new animal model of chronic MR. Left thoracotomy was performed in 34 rats. Under the guidance of transesophageal echocardiography, a fine needle was inserted into the left ventricle (LV) to damage the mitral leaflets and produce MR. Serial transthoracic echocardiography was performed to assess LV remodeling and function. Left atrial and LV diameters were significantly larger, and LV fractional shortening was lower in the MR group than in the sham group. The 150-day survival was 59% in the MR group and 100% in the sham group (P < .01). This new animal model of chronic MR may be used in the study of the pathophysiology of chronic MR and pharmacologic therapies.

Original language	English (US)
Pages (from-to)	468-474
Number of pages	7
Journal	Journal of the American Society of Echocardiography
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.echo.2004.10.005
State	Published - May 2005
Externally published	Yes
Event	Sixteenth Annual Scientific Sessions - Boston, MA, United States Duration: Jun 15 2005 → Jun 18 2005

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1016/j.echo.2004.10.005

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title = "Development of a new animal model of chronic mitral regurgitation in rats under transesophageal echocardiographic guidance",

abstract = "Large animal models (dog and sheep) are often used for the investigation of the pathophysiology of chronic mitral regurgitation (MR). A major limitation of large animal models is cost. The aim of this study was to develop a new animal model of chronic MR. Left thoracotomy was performed in 34 rats. Under the guidance of transesophageal echocardiography, a fine needle was inserted into the left ventricle (LV) to damage the mitral leaflets and produce MR. Serial transthoracic echocardiography was performed to assess LV remodeling and function. Left atrial and LV diameters were significantly larger, and LV fractional shortening was lower in the MR group than in the sham group. The 150-day survival was 59% in the MR group and 100% in the sham group (P < .01). This new animal model of chronic MR may be used in the study of the pathophysiology of chronic MR and pharmacologic therapies.",

author = "Min Pu and Zhaohui Gao and Jianhua Li and Lawrence Sinoway and Davidson, {William R.}",

year = "2005",

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AU - Pu, Min

AU - Gao, Zhaohui

AU - Li, Jianhua

AU - Sinoway, Lawrence

AU - Davidson, William R.

PY - 2005/5

Y1 - 2005/5

N2 - Large animal models (dog and sheep) are often used for the investigation of the pathophysiology of chronic mitral regurgitation (MR). A major limitation of large animal models is cost. The aim of this study was to develop a new animal model of chronic MR. Left thoracotomy was performed in 34 rats. Under the guidance of transesophageal echocardiography, a fine needle was inserted into the left ventricle (LV) to damage the mitral leaflets and produce MR. Serial transthoracic echocardiography was performed to assess LV remodeling and function. Left atrial and LV diameters were significantly larger, and LV fractional shortening was lower in the MR group than in the sham group. The 150-day survival was 59% in the MR group and 100% in the sham group (P < .01). This new animal model of chronic MR may be used in the study of the pathophysiology of chronic MR and pharmacologic therapies.

AB - Large animal models (dog and sheep) are often used for the investigation of the pathophysiology of chronic mitral regurgitation (MR). A major limitation of large animal models is cost. The aim of this study was to develop a new animal model of chronic MR. Left thoracotomy was performed in 34 rats. Under the guidance of transesophageal echocardiography, a fine needle was inserted into the left ventricle (LV) to damage the mitral leaflets and produce MR. Serial transthoracic echocardiography was performed to assess LV remodeling and function. Left atrial and LV diameters were significantly larger, and LV fractional shortening was lower in the MR group than in the sham group. The 150-day survival was 59% in the MR group and 100% in the sham group (P < .01). This new animal model of chronic MR may be used in the study of the pathophysiology of chronic MR and pharmacologic therapies.

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ER -

Development of a new animal model of chronic mitral regurgitation in rats under transesophageal echocardiographic guidance

Abstract

ASJC Scopus subject areas

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