Development and therapeutic applications of nitric oxide releasing materials to treat erectile dysfunction

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Abstract

The role of nitric oxide (NO) in erectile physiology is well documented. NO activates relaxation of corporal cavernosal smooth muscle tissue resulting in increased blood flow into the penis resulting in an erection. At present, pharmacologic treatments for erectile dysfunction, such as the phosphodiesterase-5 inhibitors, potentiate the erectile response generated by NO. However, a new class of treatments at a preclinical stage may allow localized delivery of NO to the penis via cutaneous application. These treatments may be of particular value to patients with a neurogenic component to their erectile dysfunction, and may act synergistically with phosphodiesterase-5 inhibitors to increase their efficacy.

Original languageEnglish (US)
Article numberFSO53
JournalFuture Science OA
Volume1
Issue number1
DOIs
Publication statusPublished - Aug 1 2015

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Keywords

  • ED
  • erectile dysfunction
  • nanoparticles
  • nitric oxide
  • NO
  • PDE5 inhibitors
  • phosphodiesterase-5 inhibitors

ASJC Scopus subject areas

  • Biotechnology

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