Development and preliminary experience with an ease of Extractability Rating System for prescription opioids

N. P. Katz, D. C. Buse, S. H. Budman, S. Wing Venuti, K. C. Fernandez, C. Benoit, R. Bianchi, D. Cooper, D. R. Jasinski, D. E. Smith, S. F. Butler

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

One important factor in the abuse potential of an opioid product is the ease with which active drug can be extracted. There are currently no standards for testing or reporting extractability. This article describes the development of an Extractability Rating System for use by the pharmaceutical industry and regulators. Despite several limitations, this effort serves as a call for standardized testing and reporting so that products can be accurately rated, and should help establish goals for drug developers who wish to develop "abuse-resistant" opioid products.

Original languageEnglish (US)
Pages (from-to)727-746
Number of pages20
JournalDrug Development and Industrial Pharmacy
Volume32
Issue number6
DOIs
StatePublished - Jun 1 2006
Externally publishedYes

Fingerprint

Opioid Analgesics
Prescriptions
Drug Industry
Pharmaceutical Preparations
Testing
Industry

Keywords

  • Controlled Substances Act
  • Extractability
  • Narcotic
  • Opioid
  • Substance abuse

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Molecular Medicine

Cite this

Katz, N. P., Buse, D. C., Budman, S. H., Wing Venuti, S., Fernandez, K. C., Benoit, C., ... Butler, S. F. (2006). Development and preliminary experience with an ease of Extractability Rating System for prescription opioids. Drug Development and Industrial Pharmacy, 32(6), 727-746. https://doi.org/10.1080/03639040500529093

Development and preliminary experience with an ease of Extractability Rating System for prescription opioids. / Katz, N. P.; Buse, D. C.; Budman, S. H.; Wing Venuti, S.; Fernandez, K. C.; Benoit, C.; Bianchi, R.; Cooper, D.; Jasinski, D. R.; Smith, D. E.; Butler, S. F.

In: Drug Development and Industrial Pharmacy, Vol. 32, No. 6, 01.06.2006, p. 727-746.

Research output: Contribution to journalArticle

Katz, NP, Buse, DC, Budman, SH, Wing Venuti, S, Fernandez, KC, Benoit, C, Bianchi, R, Cooper, D, Jasinski, DR, Smith, DE & Butler, SF 2006, 'Development and preliminary experience with an ease of Extractability Rating System for prescription opioids', Drug Development and Industrial Pharmacy, vol. 32, no. 6, pp. 727-746. https://doi.org/10.1080/03639040500529093
Katz, N. P. ; Buse, D. C. ; Budman, S. H. ; Wing Venuti, S. ; Fernandez, K. C. ; Benoit, C. ; Bianchi, R. ; Cooper, D. ; Jasinski, D. R. ; Smith, D. E. ; Butler, S. F. / Development and preliminary experience with an ease of Extractability Rating System for prescription opioids. In: Drug Development and Industrial Pharmacy. 2006 ; Vol. 32, No. 6. pp. 727-746.
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