Development and maintenance of neuronal architecture at the ventral midline of C. elegans

Oliver Hobert, Hannes Bülow

Research output: Contribution to journalReview article

23 Scopus citations


Work in flies, nematodes and vertebrates has shown that genes involved in axon patterning at the ventral midline are functionally conserved across phylogeny. Recent studies in Caenorhabditis elegans have implicated several new extracellular molecules, such as nidogen and heparan sulfate proteoglycans, in axonal tract formation at the midline. Furthermore, a conceptually new mechanism that regulates the maintenance of axon positioning at the midline has been described in C. elegans.

Original languageEnglish (US)
Pages (from-to)70-78
Number of pages9
JournalCurrent Opinion in Neurobiology
Issue number1
StatePublished - Feb 2003
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)

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