Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research

Lindsay G. Wich, Heather K. Hamilton, Richard L. Shapiro, Anna Pavlick, Russell S. Berman, David Polsky, Judith D. Goldberg, Eva Hernando, Prashiela Manga, Michelle Krogsgaard, Hideko Kamino, Farbod Darvishian, Peng Lee, Seth J. Orlow, Harry Oster, Nina Bhardwaj, Iman Osman

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Several challenges face the development and operation of a biospecimen bank linked to clinical information, a critical component of any effective translational research program. Melanoma adds particular complexity and difficulty to such an endeavor considering the unique characteristics of this malignancy. We describe here a review of biospecimen bank and our experience in establishing a multi-disciplinary, prospective, integrated clinicopathological-biospecimen database in melanoma. The Interdisciplinary Melanoma Cooperative Group (IMCG), a prospective clinicopathological and biospecimen database, was established at the New York University (NYU) Langone Medical Center. With patients' informed consent, biospecimens from within and outside NYU, clinicopathological data, and follow-up information are collected using developed protocols. Information pertaining to biospecimens is recorded in 35 fields, and clinicopathological information is recorded in 371 fields within 5 modules in a virtual network system. Investigators conducting research utilizing the IMCG biospecimen resource are blind to clinicopathological information, and molecular data generated using biospecimens are linked independently with clinicopathological data by biostatistics investigators. This translational research enterprise acts as a valuable resource to efficiently translate laboratory discoveries to the clinic.

Original languageEnglish (US)
Pages (from-to)35-43
Number of pages9
JournalAmerican Journal of Translational Research
Volume1
Issue number1
StatePublished - 2009

Keywords

  • Clinical database
  • Melanoma
  • Model
  • Specimen bank
  • Translational medicine

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

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