Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research

Lindsay G. Wich, Heather K. Hamilton, Richard L. Shapiro, Anna Pavlick, Russell S. Berman, David Polsky, Judith D. Goldberg, Eva Hernando, Prashiela Manga, Michelle Krogsgaard, Hideko Kamino, Farbod Darvishian, Peng Lee, Seth J. Orlow, Harry Ostrer, Nina Bhardwaj, Iman Osman

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Several challenges face the development and operation of a biospecimen bank linked to clinical information, a critical component of any effective translational research program. Melanoma adds particular complexity and difficulty to such an endeavor considering the unique characteristics of this malignancy. We describe here a review of biospecimen bank and our experience in establishing a multi-disciplinary, prospective, integrated clinicopathological-biospecimen database in melanoma. The Interdisciplinary Melanoma Cooperative Group (IMCG), a prospective clinicopathological and biospecimen database, was established at the New York University (NYU) Langone Medical Center. With patients' informed consent, biospecimens from within and outside NYU, clinicopathological data, and follow-up information are collected using developed protocols. Information pertaining to biospecimens is recorded in 35 fields, and clinicopathological information is recorded in 371 fields within 5 modules in a virtual network system. Investigators conducting research utilizing the IMCG biospecimen resource are blind to clinicopathological information, and molecular data generated using biospecimens are linked independently with clinicopathological data by biostatistics investigators. This translational research enterprise acts as a valuable resource to efficiently translate laboratory discoveries to the clinic.

Original languageEnglish (US)
Pages (from-to)35-43
Number of pages9
JournalAmerican Journal of Translational Research
Volume1
Issue number1
StatePublished - 2009

Fingerprint

Translational Medical Research
Melanoma
User-Computer Interface
Research Personnel
Biostatistics
Databases
Informed Consent
Industry
Research
Neoplasms

Keywords

  • Clinical database
  • Melanoma
  • Model
  • Specimen bank
  • Translational medicine

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Wich, L. G., Hamilton, H. K., Shapiro, R. L., Pavlick, A., Berman, R. S., Polsky, D., ... Osman, I. (2009). Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research. American Journal of Translational Research, 1(1), 35-43.

Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research. / Wich, Lindsay G.; Hamilton, Heather K.; Shapiro, Richard L.; Pavlick, Anna; Berman, Russell S.; Polsky, David; Goldberg, Judith D.; Hernando, Eva; Manga, Prashiela; Krogsgaard, Michelle; Kamino, Hideko; Darvishian, Farbod; Lee, Peng; Orlow, Seth J.; Ostrer, Harry; Bhardwaj, Nina; Osman, Iman.

In: American Journal of Translational Research, Vol. 1, No. 1, 2009, p. 35-43.

Research output: Contribution to journalArticle

Wich, LG, Hamilton, HK, Shapiro, RL, Pavlick, A, Berman, RS, Polsky, D, Goldberg, JD, Hernando, E, Manga, P, Krogsgaard, M, Kamino, H, Darvishian, F, Lee, P, Orlow, SJ, Ostrer, H, Bhardwaj, N & Osman, I 2009, 'Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research', American Journal of Translational Research, vol. 1, no. 1, pp. 35-43.
Wich, Lindsay G. ; Hamilton, Heather K. ; Shapiro, Richard L. ; Pavlick, Anna ; Berman, Russell S. ; Polsky, David ; Goldberg, Judith D. ; Hernando, Eva ; Manga, Prashiela ; Krogsgaard, Michelle ; Kamino, Hideko ; Darvishian, Farbod ; Lee, Peng ; Orlow, Seth J. ; Ostrer, Harry ; Bhardwaj, Nina ; Osman, Iman. / Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research. In: American Journal of Translational Research. 2009 ; Vol. 1, No. 1. pp. 35-43.
@article{816724f0d2264d4da0352f7001d892ed,
title = "Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research",
abstract = "Several challenges face the development and operation of a biospecimen bank linked to clinical information, a critical component of any effective translational research program. Melanoma adds particular complexity and difficulty to such an endeavor considering the unique characteristics of this malignancy. We describe here a review of biospecimen bank and our experience in establishing a multi-disciplinary, prospective, integrated clinicopathological-biospecimen database in melanoma. The Interdisciplinary Melanoma Cooperative Group (IMCG), a prospective clinicopathological and biospecimen database, was established at the New York University (NYU) Langone Medical Center. With patients' informed consent, biospecimens from within and outside NYU, clinicopathological data, and follow-up information are collected using developed protocols. Information pertaining to biospecimens is recorded in 35 fields, and clinicopathological information is recorded in 371 fields within 5 modules in a virtual network system. Investigators conducting research utilizing the IMCG biospecimen resource are blind to clinicopathological information, and molecular data generated using biospecimens are linked independently with clinicopathological data by biostatistics investigators. This translational research enterprise acts as a valuable resource to efficiently translate laboratory discoveries to the clinic.",
keywords = "Clinical database, Melanoma, Model, Specimen bank, Translational medicine",
author = "Wich, {Lindsay G.} and Hamilton, {Heather K.} and Shapiro, {Richard L.} and Anna Pavlick and Berman, {Russell S.} and David Polsky and Goldberg, {Judith D.} and Eva Hernando and Prashiela Manga and Michelle Krogsgaard and Hideko Kamino and Farbod Darvishian and Peng Lee and Orlow, {Seth J.} and Harry Ostrer and Nina Bhardwaj and Iman Osman",
year = "2009",
language = "English (US)",
volume = "1",
pages = "35--43",
journal = "American Journal of Translational Research",
issn = "1943-8141",
publisher = "e-Century Publishing Corporation",
number = "1",

}

TY - JOUR

T1 - Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research

AU - Wich, Lindsay G.

AU - Hamilton, Heather K.

AU - Shapiro, Richard L.

AU - Pavlick, Anna

AU - Berman, Russell S.

AU - Polsky, David

AU - Goldberg, Judith D.

AU - Hernando, Eva

AU - Manga, Prashiela

AU - Krogsgaard, Michelle

AU - Kamino, Hideko

AU - Darvishian, Farbod

AU - Lee, Peng

AU - Orlow, Seth J.

AU - Ostrer, Harry

AU - Bhardwaj, Nina

AU - Osman, Iman

PY - 2009

Y1 - 2009

N2 - Several challenges face the development and operation of a biospecimen bank linked to clinical information, a critical component of any effective translational research program. Melanoma adds particular complexity and difficulty to such an endeavor considering the unique characteristics of this malignancy. We describe here a review of biospecimen bank and our experience in establishing a multi-disciplinary, prospective, integrated clinicopathological-biospecimen database in melanoma. The Interdisciplinary Melanoma Cooperative Group (IMCG), a prospective clinicopathological and biospecimen database, was established at the New York University (NYU) Langone Medical Center. With patients' informed consent, biospecimens from within and outside NYU, clinicopathological data, and follow-up information are collected using developed protocols. Information pertaining to biospecimens is recorded in 35 fields, and clinicopathological information is recorded in 371 fields within 5 modules in a virtual network system. Investigators conducting research utilizing the IMCG biospecimen resource are blind to clinicopathological information, and molecular data generated using biospecimens are linked independently with clinicopathological data by biostatistics investigators. This translational research enterprise acts as a valuable resource to efficiently translate laboratory discoveries to the clinic.

AB - Several challenges face the development and operation of a biospecimen bank linked to clinical information, a critical component of any effective translational research program. Melanoma adds particular complexity and difficulty to such an endeavor considering the unique characteristics of this malignancy. We describe here a review of biospecimen bank and our experience in establishing a multi-disciplinary, prospective, integrated clinicopathological-biospecimen database in melanoma. The Interdisciplinary Melanoma Cooperative Group (IMCG), a prospective clinicopathological and biospecimen database, was established at the New York University (NYU) Langone Medical Center. With patients' informed consent, biospecimens from within and outside NYU, clinicopathological data, and follow-up information are collected using developed protocols. Information pertaining to biospecimens is recorded in 35 fields, and clinicopathological information is recorded in 371 fields within 5 modules in a virtual network system. Investigators conducting research utilizing the IMCG biospecimen resource are blind to clinicopathological information, and molecular data generated using biospecimens are linked independently with clinicopathological data by biostatistics investigators. This translational research enterprise acts as a valuable resource to efficiently translate laboratory discoveries to the clinic.

KW - Clinical database

KW - Melanoma

KW - Model

KW - Specimen bank

KW - Translational medicine

UR - http://www.scopus.com/inward/record.url?scp=77953390501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953390501&partnerID=8YFLogxK

M3 - Article

C2 - 19966936

AN - SCOPUS:77953390501

VL - 1

SP - 35

EP - 43

JO - American Journal of Translational Research

JF - American Journal of Translational Research

SN - 1943-8141

IS - 1

ER -