Determining the maximal length of a vein conduit used as an interposition graft for nerve regeneration

Berish Strauch, Michael Ferder, Susan Lovelle-Allen, Keith Moore, D. J. Kim, Josephine Llena

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Although autogenous veins have been used as nerve conduits (AVNCs) both experimentally and clinically for short nerve gaps up to 3 cm, investigators have not as yet determined the maximal effective length for functional nerve regeneration. In addition, the role of the distal nerve stump on subsequent nerve growth remains unclear. A rabbit peroneal nerve AVNC model was used to study axonal regeneration through nerve gaps of 1 to 6 cm. After allowing ample time for nerve regeneration, clinical, electrophysiologic, and neurohistologic studies were performed to evaluate nerve growth and functional muscle reinnervation. Comparisons were made with 6-cm conventional nerve grafts. Excellent growth and function were found with AVNCs up to 3 cm in length, with increasing incapacity for regeneration at lengths greater than 3 cm. The distal nerve stump is believed to play a vital role in nerve regrowth.

Original languageEnglish (US)
Pages (from-to)521-527
Number of pages7
JournalJournal of Reconstructive Microsurgery
Volume12
Issue number8
StatePublished - Nov 1996

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Nerve Regeneration
Veins
Transplants
Growth
Peroneal Nerve
Regeneration
Research Personnel
Rabbits
Muscles

ASJC Scopus subject areas

  • Surgery

Cite this

Strauch, B., Ferder, M., Lovelle-Allen, S., Moore, K., Kim, D. J., & Llena, J. (1996). Determining the maximal length of a vein conduit used as an interposition graft for nerve regeneration. Journal of Reconstructive Microsurgery, 12(8), 521-527.

Determining the maximal length of a vein conduit used as an interposition graft for nerve regeneration. / Strauch, Berish; Ferder, Michael; Lovelle-Allen, Susan; Moore, Keith; Kim, D. J.; Llena, Josephine.

In: Journal of Reconstructive Microsurgery, Vol. 12, No. 8, 11.1996, p. 521-527.

Research output: Contribution to journalArticle

Strauch, B, Ferder, M, Lovelle-Allen, S, Moore, K, Kim, DJ & Llena, J 1996, 'Determining the maximal length of a vein conduit used as an interposition graft for nerve regeneration', Journal of Reconstructive Microsurgery, vol. 12, no. 8, pp. 521-527.
Strauch, Berish ; Ferder, Michael ; Lovelle-Allen, Susan ; Moore, Keith ; Kim, D. J. ; Llena, Josephine. / Determining the maximal length of a vein conduit used as an interposition graft for nerve regeneration. In: Journal of Reconstructive Microsurgery. 1996 ; Vol. 12, No. 8. pp. 521-527.
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