Determinants of mRNA localization

Edward H. Kislauskis, Robert H. Singer

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


RNA localization provides a mechanism for protein targeting within developing or differentiating cells. Specific cis-acting sequences on mRNA mediate this process. Such 'localizer' or 'zipcode' nucleic acid sequences have been restricted to the 3′ untranslated region of several mRNAs. The presence of genetic information denoting a spatial component of translation adds a new dimension to gene expression.

Original languageEnglish (US)
Pages (from-to)975-978
Number of pages4
JournalCurrent Opinion in Cell Biology
Issue number6
StatePublished - Dec 1992
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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