Detection of the major rheumatoid factor cross-reactive idiotype precedes human IgG binding activity in a patient with polyarticular juvenile rheumatoid arthritis

Norman Todd Ilowite, J. F. Wedgwood, D. Valacer, L. Hatam, T. Ramakrishnan, V. R. Bonagura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A patient with polyarthritis and subcutaneous nodules was studied for expression of rheumatoid factors (RF) by numerous techniques for 5 months after presentation. Assays for RF binding human or rabbit IgG in whole sera, assays for hidden RF binding human or rabbit IgG, and assays for expression of the major RF cross-reactive idiotype (RCRI) in whole sera or by pokeweed mitogen induced plasma cells were performed (PWM-PC). In this patient, increased expression of RCRI in sera and among PWM-PC preceded detectable RF binding human IgG, and paralleled hidden RF and RF binding rabbit IgG expression.

Original languageEnglish (US)
Pages (from-to)1789-1792
Number of pages4
JournalJournal of Rheumatology
Volume15
Issue number12
StatePublished - 1988

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Juvenile Arthritis
Rheumatoid Factor
Immunoglobulin G
Rabbits
Serum
Pokeweed Mitogens
Plasma Cells
Arthritis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Ilowite, N. T., Wedgwood, J. F., Valacer, D., Hatam, L., Ramakrishnan, T., & Bonagura, V. R. (1988). Detection of the major rheumatoid factor cross-reactive idiotype precedes human IgG binding activity in a patient with polyarticular juvenile rheumatoid arthritis. Journal of Rheumatology, 15(12), 1789-1792.

Detection of the major rheumatoid factor cross-reactive idiotype precedes human IgG binding activity in a patient with polyarticular juvenile rheumatoid arthritis. / Ilowite, Norman Todd; Wedgwood, J. F.; Valacer, D.; Hatam, L.; Ramakrishnan, T.; Bonagura, V. R.

In: Journal of Rheumatology, Vol. 15, No. 12, 1988, p. 1789-1792.

Research output: Contribution to journalArticle

Ilowite, Norman Todd ; Wedgwood, J. F. ; Valacer, D. ; Hatam, L. ; Ramakrishnan, T. ; Bonagura, V. R. / Detection of the major rheumatoid factor cross-reactive idiotype precedes human IgG binding activity in a patient with polyarticular juvenile rheumatoid arthritis. In: Journal of Rheumatology. 1988 ; Vol. 15, No. 12. pp. 1789-1792.
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