Detection of precancerous cervical lesions is differential by human papillomavirus type

Mahboobeh Safaeian, Mark Schiffman, Julia Gage, Diane Solomon, Cosette M. Wheeler, Philip E. Castle

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Epidemiologic studies have reported the underrepresentation of cervical precancerous lesions caused by human papillomavirus (HPV) types 18 and 45 (HPV18/45) compared with the proportion of cervical cancers attributed to these HPV types. We investigated the timing of diagnosis of histologic cervical intraepithelial neoplasia grade 3 or worse (CIN3+) using data from the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study (ALTS). Of the 2,725 women who underwent enrollment colposcopy, 412 of 472 (87.3%) diagnosed with histologic CIN3+ over the 2-year duration of ALTS could be assigned to a HPV type or group of types and were included in this analysis. Eighty-four percent of HPV16-positive CIN3+ were diagnosed at enrollment, compared with 57% of HPV18/45-positive C1N3+, and 58% of C1N3 positive for other carcinogenic HPV types at enrollment. In contrast, only 8% of HPV16-positive CIN3+ were diagnosed at exit, whereas 31% were HPV18/45 positive and 22% were positive for other carcinogenic types at study exit (P<0.001). These results indicate the underrepresentation of HPV18/45 in precancers, whereas HPV16- associated C1N3+ is diagnosed much earlier. Whether the underrepresentation of 18/45 may be due to occult pathology needs further investigation.

Original languageEnglish (US)
Pages (from-to)3262-3266
Number of pages5
JournalCancer Research
Volume69
Issue number8
DOIs
StatePublished - Apr 15 2009
Externally publishedYes

Fingerprint

Human papillomavirus 18
Colposcopy
Cervical Intraepithelial Neoplasia
Triage
Uterine Cervical Neoplasms
Epidemiologic Studies
Pathology

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Detection of precancerous cervical lesions is differential by human papillomavirus type. / Safaeian, Mahboobeh; Schiffman, Mark; Gage, Julia; Solomon, Diane; Wheeler, Cosette M.; Castle, Philip E.

In: Cancer Research, Vol. 69, No. 8, 15.04.2009, p. 3262-3266.

Research output: Contribution to journalArticle

Safaeian, Mahboobeh ; Schiffman, Mark ; Gage, Julia ; Solomon, Diane ; Wheeler, Cosette M. ; Castle, Philip E. / Detection of precancerous cervical lesions is differential by human papillomavirus type. In: Cancer Research. 2009 ; Vol. 69, No. 8. pp. 3262-3266.
@article{97e8667eaac64be6802e3d0029a95064,
title = "Detection of precancerous cervical lesions is differential by human papillomavirus type",
abstract = "Epidemiologic studies have reported the underrepresentation of cervical precancerous lesions caused by human papillomavirus (HPV) types 18 and 45 (HPV18/45) compared with the proportion of cervical cancers attributed to these HPV types. We investigated the timing of diagnosis of histologic cervical intraepithelial neoplasia grade 3 or worse (CIN3+) using data from the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study (ALTS). Of the 2,725 women who underwent enrollment colposcopy, 412 of 472 (87.3{\%}) diagnosed with histologic CIN3+ over the 2-year duration of ALTS could be assigned to a HPV type or group of types and were included in this analysis. Eighty-four percent of HPV16-positive CIN3+ were diagnosed at enrollment, compared with 57{\%} of HPV18/45-positive C1N3+, and 58{\%} of C1N3 positive for other carcinogenic HPV types at enrollment. In contrast, only 8{\%} of HPV16-positive CIN3+ were diagnosed at exit, whereas 31{\%} were HPV18/45 positive and 22{\%} were positive for other carcinogenic types at study exit (P<0.001). These results indicate the underrepresentation of HPV18/45 in precancers, whereas HPV16- associated C1N3+ is diagnosed much earlier. Whether the underrepresentation of 18/45 may be due to occult pathology needs further investigation.",
author = "Mahboobeh Safaeian and Mark Schiffman and Julia Gage and Diane Solomon and Wheeler, {Cosette M.} and Castle, {Philip E.}",
year = "2009",
month = "4",
day = "15",
doi = "10.1158/0008-5472.CAN-08-4192",
language = "English (US)",
volume = "69",
pages = "3262--3266",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "8",

}

TY - JOUR

T1 - Detection of precancerous cervical lesions is differential by human papillomavirus type

AU - Safaeian, Mahboobeh

AU - Schiffman, Mark

AU - Gage, Julia

AU - Solomon, Diane

AU - Wheeler, Cosette M.

AU - Castle, Philip E.

PY - 2009/4/15

Y1 - 2009/4/15

N2 - Epidemiologic studies have reported the underrepresentation of cervical precancerous lesions caused by human papillomavirus (HPV) types 18 and 45 (HPV18/45) compared with the proportion of cervical cancers attributed to these HPV types. We investigated the timing of diagnosis of histologic cervical intraepithelial neoplasia grade 3 or worse (CIN3+) using data from the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study (ALTS). Of the 2,725 women who underwent enrollment colposcopy, 412 of 472 (87.3%) diagnosed with histologic CIN3+ over the 2-year duration of ALTS could be assigned to a HPV type or group of types and were included in this analysis. Eighty-four percent of HPV16-positive CIN3+ were diagnosed at enrollment, compared with 57% of HPV18/45-positive C1N3+, and 58% of C1N3 positive for other carcinogenic HPV types at enrollment. In contrast, only 8% of HPV16-positive CIN3+ were diagnosed at exit, whereas 31% were HPV18/45 positive and 22% were positive for other carcinogenic types at study exit (P<0.001). These results indicate the underrepresentation of HPV18/45 in precancers, whereas HPV16- associated C1N3+ is diagnosed much earlier. Whether the underrepresentation of 18/45 may be due to occult pathology needs further investigation.

AB - Epidemiologic studies have reported the underrepresentation of cervical precancerous lesions caused by human papillomavirus (HPV) types 18 and 45 (HPV18/45) compared with the proportion of cervical cancers attributed to these HPV types. We investigated the timing of diagnosis of histologic cervical intraepithelial neoplasia grade 3 or worse (CIN3+) using data from the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study (ALTS). Of the 2,725 women who underwent enrollment colposcopy, 412 of 472 (87.3%) diagnosed with histologic CIN3+ over the 2-year duration of ALTS could be assigned to a HPV type or group of types and were included in this analysis. Eighty-four percent of HPV16-positive CIN3+ were diagnosed at enrollment, compared with 57% of HPV18/45-positive C1N3+, and 58% of C1N3 positive for other carcinogenic HPV types at enrollment. In contrast, only 8% of HPV16-positive CIN3+ were diagnosed at exit, whereas 31% were HPV18/45 positive and 22% were positive for other carcinogenic types at study exit (P<0.001). These results indicate the underrepresentation of HPV18/45 in precancers, whereas HPV16- associated C1N3+ is diagnosed much earlier. Whether the underrepresentation of 18/45 may be due to occult pathology needs further investigation.

UR - http://www.scopus.com/inward/record.url?scp=65949110864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65949110864&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-08-4192

DO - 10.1158/0008-5472.CAN-08-4192

M3 - Article

C2 - 19351830

AN - SCOPUS:65949110864

VL - 69

SP - 3262

EP - 3266

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 8

ER -