Detection of human papillomavirus deoxyribonucleic acid from vulvar dystrophies and vulvar intraepithelial neoplastic lesions

Mickey Karram, Bannie Tabor, David Smotkin, Felix Wettstein, Narender Bhatia, John Micha

Research output: Contribution to journalArticle

20 Scopus citations


Vulvar biopsy specimens from 16 patients with gross lesions of the vulva consistent with vulvar dystrophy were examined histologically and for the presence of human papillomavirus deoxyribonucleic acid by southern blot hybridization. None of the nonatypical dystrophies probed positive for human papillomavirus; however, three of five atypical hyperplastic dystrophies (vulvar intraepithelial neoplasia) contained human papillomavirus deoxyribonucleic acid type 16. We conclude that human papillomavirus does not seem to be a causal factor in nonatypical chronic epithelial changes of the vulva.

Original languageEnglish (US)
Pages (from-to)22-23
Number of pages2
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
Publication statusPublished - Jul 1988
Externally publishedYes



  • Dystrophy
  • human papillomavirus
  • vulvar intraepithelial neoplasia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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