Detection of cervical cancer and its precursors by endocervical curettage in 13,115 colposcopically guided biopsy examinations

Julia C. Gage, Mire A. Duggan, Jill G. Nation, Song Gao, Philip E. Castle

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Objective: Endocervical curettage (ECC) specimens obtained during colposcopy can detect cervical cancer and precursors otherwise missed by biopsy alone, but the procedure can be painful and reduce compliance with needed follow-up. ECC is routinely performed in the Calgary Health Region colposcopy clinics, permitting a look at its real-world utility. Study Design: We analyzed pathology and colposcopy reports from 2003 to 2007. We calculated the added diagnostic utility of ECC compared with cervical biopsy alone. Results: ECC increased the diagnostic yield of cervical intraepithelial neoplasia grade 2 or worse (cervical intraepithelial neoplasia [CIN]2+) in 1.01% of 13,115 colposcopically guided biopsy examinations. Therefore, 99 ECC specimens were taken to detect 1 additional CIN2+. ECC detected 5.4% of 2443 CIN2+ subjects otherwise missed by biopsy alone. Utility was greatest among women aged 46 years or older referred after a high-grade cytology. Conclusion: ECC is rarely informative when used routinely in colposcopic practice. Older women referred after high-risk cytology benefit most from ECC.

Original languageEnglish (US)
Pages (from-to)481.e1-481.e9
JournalAmerican Journal of Obstetrics and Gynecology
Volume203
Issue number5
DOIs
StatePublished - Nov 2010
Externally publishedYes

Keywords

  • cervical intraepithelial neoplasia
  • colposcopy
  • curettage
  • diagnosis
  • endocervical sampling

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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