Detection of α-transducin in retinal rods but not cones

Gerald B. Grunwald; Peter Gierschik; Marshall Nirenberg; Allen Spiegel

doi:10.1126/science.3080807

Detection of α-transducin in retinal rods but not cones

Gerald B. Grunwald, Peter Gierschik, Marshall Nirenberg, Allen Spiegel

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

Original language	English (US)
Pages (from-to)	856-859
Number of pages	4
Journal	Science
Volume	231
Issue number	4740
DOIs	https://doi.org/10.1126/science.3080807
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.3080807

Cite this

@article{6a0a3ffb820a4bd2927900e6e5baa7e7,

title = "Detection of α-transducin in retinal rods but not cones",

abstract = "The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.",

author = "Grunwald, {Gerald B.} and Peter Gierschik and Marshall Nirenberg and Allen Spiegel",

year = "1986",

doi = "10.1126/science.3080807",

language = "English (US)",

volume = "231",

pages = "856--859",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4740",

}

TY - JOUR

T1 - Detection of α-transducin in retinal rods but not cones

AU - Grunwald, Gerald B.

AU - Gierschik, Peter

AU - Nirenberg, Marshall

AU - Spiegel, Allen

PY - 1986

Y1 - 1986

N2 - The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

AB - The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

UR - http://www.scopus.com/inward/record.url?scp=0022655936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022655936&partnerID=8YFLogxK

U2 - 10.1126/science.3080807

DO - 10.1126/science.3080807

M3 - Article

C2 - 3080807

AN - SCOPUS:0022655936

SN - 0036-8075

VL - 231

SP - 856

EP - 859

JO - Science

JF - Science

IS - 4740

ER -

Detection of α-transducin in retinal rods but not cones

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this