Detection and isolation of dendritic cells using Lewis X-functionalized magnetic nanoparticles

Sara H. Rouhanifard, Ran Xie, Guoxin Zhang, Xiaoming Sun, Xing Chen, Peng Wu

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

dendritic cell (DC)-specific intracellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) is a receptor found on DCs that recognizes antigens bearing mannose-rich or fucosylated glycans, including Lewis X (LeX). Here, we report the fabrication of magnetic nanoparticles coated with multivalent LeX glycans using Cu (I)-catalyzed azide-alkyne cycloaddition. The resulting nanoparticles are selective and biocompatible, serving as a highly efficient tool for DC detection and enrichment.

Original languageEnglish (US)
Pages (from-to)3039-3045
Number of pages7
JournalBiomacromolecules
Volume13
Issue number10
DOIs
StatePublished - Oct 8 2012

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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