Detailed Genetic and Physical Map of the 3p Chromosome Region Surrounding the Familial Renal Cell Carcinoma Chromosome Translocation, t(3;8)(pl4.2;q24.1)

Sal LaForgia, Jerzy Lasota, Farida Latif, Leslie Boghosian-Sell, Kumar Kastury, Masataka Ohta, Teresa Druck, Lakshmi Atchison, Linda A. Cannizzaro, Gilad Barnea, Joseph Schlessinger, William Modi, Igor Kuzmin, Kalman Tory, Berton Zbar, Carlo M. Croce, Michael Lerman, Kay Huebner

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Extensive studies of loss of heterozygosity of 3p markers in renal cell carcinomas (RCCs) have established that there are at least three regions critical in kidney tumorigenesis, one most likely coincident with the von Hippel-Lindau gene at 3p25 J, one in 3p21 which may also be critical in small cell lung carcinomas, and one in 3pl3-pl4.2, a region which includes the 3p chromosome translocation break of familial RCC with the t(3;8)-(pl4.2;q24.1) translocation. A panel of rodent-human hybrids carrying portions of 3p, including a hybrid carrying the derivative 8 (der(8)(8pter→8q24.1::3pl4.2→3pter)) from the RCC family, have been characterized using 3p anchor probes and cytogenetic methods. This 3p panel was then used to map a large number of genetically mapped probes into seven physical intervals between 3pl2 and 3pter defined by the hybrid panel. Markers have been physically, and some genetically, placed relative to the t(3;8) break, such that positional cloning of the break is feasible.

Original languageEnglish (US)
Pages (from-to)3118-3124
Number of pages7
JournalCancer research
Volume53
Issue number13
StatePublished - Jul 1993

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    LaForgia, S., Lasota, J., Latif, F., Boghosian-Sell, L., Kastury, K., Ohta, M., Druck, T., Atchison, L., Cannizzaro, L. A., Barnea, G., Schlessinger, J., Modi, W., Kuzmin, I., Tory, K., Zbar, B., Croce, C. M., Lerman, M., & Huebner, K. (1993). Detailed Genetic and Physical Map of the 3p Chromosome Region Surrounding the Familial Renal Cell Carcinoma Chromosome Translocation, t(3;8)(pl4.2;q24.1). Cancer research, 53(13), 3118-3124.