Detachment of desmosomes in a microcystic meningioma.

S. Matsui, T. Matsui, A. Hirano

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This report demonstrates the detachment of desmosomes in the microcystic area of a frontal convexity meningioma removed from a 69-year-old woman. Well-developed interdigitations of the tumor cell processes with numerous desmosomes and with narrow extracellular spaces were characteristic features of the solid area of the meningioma. By contrast, the microcystic area of the tumor had markedly distended extracellular spaces. Various stages in the separation of desmosomal attachments were seen in this area. The observed configurations ranged from the widening of opposing junctions to the formation of large cavities where hemidesmosome-like structures were evident. The latter lacked basal lamina, and are considered to represent a transition leading to the loss of desmosome, and thus involved in the enlargement of the extracellular space in microcystic meningiomas.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalNōshuyō byōri = Brain tumor pathology
Volume12
Issue number2
StatePublished - 1995
Externally publishedYes

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Desmosomes
Extracellular Space
Meningioma
Hemidesmosomes
Basement Membrane
Neoplasms

Cite this

Matsui, S., Matsui, T., & Hirano, A. (1995). Detachment of desmosomes in a microcystic meningioma. Nōshuyō byōri = Brain tumor pathology, 12(2), 85-89.

Detachment of desmosomes in a microcystic meningioma. / Matsui, S.; Matsui, T.; Hirano, A.

In: Nōshuyō byōri = Brain tumor pathology, Vol. 12, No. 2, 1995, p. 85-89.

Research output: Contribution to journalArticle

Matsui, S, Matsui, T & Hirano, A 1995, 'Detachment of desmosomes in a microcystic meningioma.', Nōshuyō byōri = Brain tumor pathology, vol. 12, no. 2, pp. 85-89.
Matsui, S. ; Matsui, T. ; Hirano, A. / Detachment of desmosomes in a microcystic meningioma. In: Nōshuyō byōri = Brain tumor pathology. 1995 ; Vol. 12, No. 2. pp. 85-89.
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