Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes

Amos B. Smith, Paul V. Rucker, Ignacio Brouard, B. Scott Freeze, Shujun Xia, Susan Band Horwitz

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

(Chemical Equation Presented) The design, synthesis, and biological evaluation of a series of (+)-discodermolide molecular probes possessing photoaffinity and fluorescent appendages has been achieved. Stereoselective olefin cross-metathesis comprised a key tactic for construction of two of the molecular probes. Three photoaffinity probes were radiolabeled with tritium.

Original languageEnglish (US)
Pages (from-to)5199-5202
Number of pages4
JournalOrganic Letters
Volume7
Issue number23
DOIs
Publication statusPublished - Nov 10 2005

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this