Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes

Amos B. Smith, Paul V. Rucker, Ignacio Brouard, B. Scott Freeze, Shujun Xia, Susan Band Horwitz

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

(Chemical Equation Presented) The design, synthesis, and biological evaluation of a series of (+)-discodermolide molecular probes possessing photoaffinity and fluorescent appendages has been achieved. Stereoselective olefin cross-metathesis comprised a key tactic for construction of two of the molecular probes. Three photoaffinity probes were radiolabeled with tritium.

Original languageEnglish (US)
Pages (from-to)5199-5202
Number of pages4
JournalOrganic Letters
Volume7
Issue number23
DOIs
StatePublished - Nov 10 2005

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Molecular Probes
Tritium
evaluation
probes
Alkenes
synthesis
appendages
tactics
metathesis
tritium
alkenes
discodermolide

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes. / Smith, Amos B.; Rucker, Paul V.; Brouard, Ignacio; Freeze, B. Scott; Xia, Shujun; Band Horwitz, Susan.

In: Organic Letters, Vol. 7, No. 23, 10.11.2005, p. 5199-5202.

Research output: Contribution to journalArticle

Smith, Amos B. ; Rucker, Paul V. ; Brouard, Ignacio ; Freeze, B. Scott ; Xia, Shujun ; Band Horwitz, Susan. / Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes. In: Organic Letters. 2005 ; Vol. 7, No. 23. pp. 5199-5202.
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