Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes

Amos B. Smith; Paul V. Rucker; Ignacio Brouard; B. Scott Freeze; Shujun Xia; Susan Band Horwitz

doi:10.1021/ol0520166

Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes

Amos B. Smith, Paul V. Rucker, Ignacio Brouard, B. Scott Freeze, Shujun Xia, Susan Band Horwitz

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

(Chemical Equation Presented) The design, synthesis, and biological evaluation of a series of (+)-discodermolide molecular probes possessing photoaffinity and fluorescent appendages has been achieved. Stereoselective olefin cross-metathesis comprised a key tactic for construction of two of the molecular probes. Three photoaffinity probes were radiolabeled with tritium.

Original language	English (US)
Pages (from-to)	5199-5202
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	23
DOIs	https://doi.org/10.1021/ol0520166
State	Published - Nov 10 2005

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0520166

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title = "Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes",

abstract = "(Chemical Equation Presented) The design, synthesis, and biological evaluation of a series of (+)-discodermolide molecular probes possessing photoaffinity and fluorescent appendages has been achieved. Stereoselective olefin cross-metathesis comprised a key tactic for construction of two of the molecular probes. Three photoaffinity probes were radiolabeled with tritium.",

author = "Smith, {Amos B.} and Rucker, {Paul V.} and Ignacio Brouard and Freeze, {B. Scott} and Shujun Xia and Horwitz, {Susan Band}",

year = "2005",

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AU - Smith, Amos B.

AU - Rucker, Paul V.

AU - Brouard, Ignacio

AU - Freeze, B. Scott

AU - Xia, Shujun

AU - Horwitz, Susan Band

PY - 2005/11/10

Y1 - 2005/11/10

N2 - (Chemical Equation Presented) The design, synthesis, and biological evaluation of a series of (+)-discodermolide molecular probes possessing photoaffinity and fluorescent appendages has been achieved. Stereoselective olefin cross-metathesis comprised a key tactic for construction of two of the molecular probes. Three photoaffinity probes were radiolabeled with tritium.

AB - (Chemical Equation Presented) The design, synthesis, and biological evaluation of a series of (+)-discodermolide molecular probes possessing photoaffinity and fluorescent appendages has been achieved. Stereoselective olefin cross-metathesis comprised a key tactic for construction of two of the molecular probes. Three photoaffinity probes were radiolabeled with tritium.

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Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes

Abstract

ASJC Scopus subject areas

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