Design of the nephrotic syndrome study network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach

Crystal A. Gadegbeku, Debbie S. Gipson, Lawrence B. Holzman, Akinlolu O. Ojo, Peter X K Song, Laura Barisoni, Matthew G. Sampson, Jeffrey B. Kopp, Kevin V. Lemley, Peter J. Nelson, Chrysta C. Lienczewski, Sharon G. Adler, Gerald B. Appel, Daniel C. Cattran, Michael J. Choi, Gabriel Contreras, Katherine M. Dell, Fernando C. Fervenza, Keisha L. Gibson, Larry A. Greenbaum & 20 others Joel D. Hernandez, Stephen M. Hewitt, Sangeeta R. Hingorani, Michelle Hladunewich, Marie C. Hogan, Susan L. Hogan, Frederick J. Kaskel, John C. Lieske, Kevin E C Meyers, Patrick H. Nachman, Cynthia C. Nast, Alicia M. Neu, Heather N. Reich, John R. Sedor, Christine B. Sethna, Howard Trachtman, Katherine R. Tuttle, Olga Zhdanova, Gastòn E. Zilleruelo, Matthias Kretzler

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

The Nephrotic Syndrome Study Network (NEPTUNE) is a North American multicenter collaborative consortium established to develop a translational research infrastructure for nephrotic syndrome. This includes a longitudinal observational cohort study, a pilot and ancillary study program, a training program, and a patient contact registry. NEPTUNE will enroll 450 adults and children with minimal change disease, focal segmental glomerulosclerosis, and membranous nephropathy for detailed clinical, histopathological, and molecular phenotyping at the time of clinically indicated renal biopsy. Initial visits will include an extensive clinical history, physical examination, collection of urine, blood and renal tissue samples, and assessments of quality of life and patient-reported outcomes. Follow-up history, physical measures, urine and blood samples, and questionnaires will be obtained every 4 months in the first year and biannually, thereafter. Molecular profiles and gene expression data will be linked to phenotypic, genetic, and digitalized histological data for comprehensive analyses using systems biology approaches. Analytical strategies were designed to transform descriptive information to mechanistic disease classification for nephrotic syndrome and to identify clinical, histological, and genomic disease predictors. Thus, understanding the complexity of the disease pathogenesis will guide further investigation for targeted therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)749-756
Number of pages8
JournalKidney International
Volume83
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Nephrotic Syndrome
Lipoid Nephrosis
Kidney
Focal Segmental Glomerulosclerosis
Membranous Glomerulonephritis
Urine Specimen Collection
Translational Medical Research
Systems Biology
Transcriptome
Physical Examination
Observational Studies
Registries
Cohort Studies
History
Quality of Life
Urine
Biopsy
Education
Therapeutics

Keywords

  • clinical trial
  • focal segmental glomerulosclerosis
  • membranous nephropathy
  • nephrotic syndrome

ASJC Scopus subject areas

  • Nephrology

Cite this

Gadegbeku, C. A., Gipson, D. S., Holzman, L. B., Ojo, A. O., Song, P. X. K., Barisoni, L., ... Kretzler, M. (2013). Design of the nephrotic syndrome study network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney International, 83(4), 749-756. https://doi.org/10.1038/ki.2012.428

Design of the nephrotic syndrome study network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. / Gadegbeku, Crystal A.; Gipson, Debbie S.; Holzman, Lawrence B.; Ojo, Akinlolu O.; Song, Peter X K; Barisoni, Laura; Sampson, Matthew G.; Kopp, Jeffrey B.; Lemley, Kevin V.; Nelson, Peter J.; Lienczewski, Chrysta C.; Adler, Sharon G.; Appel, Gerald B.; Cattran, Daniel C.; Choi, Michael J.; Contreras, Gabriel; Dell, Katherine M.; Fervenza, Fernando C.; Gibson, Keisha L.; Greenbaum, Larry A.; Hernandez, Joel D.; Hewitt, Stephen M.; Hingorani, Sangeeta R.; Hladunewich, Michelle; Hogan, Marie C.; Hogan, Susan L.; Kaskel, Frederick J.; Lieske, John C.; Meyers, Kevin E C; Nachman, Patrick H.; Nast, Cynthia C.; Neu, Alicia M.; Reich, Heather N.; Sedor, John R.; Sethna, Christine B.; Trachtman, Howard; Tuttle, Katherine R.; Zhdanova, Olga; Zilleruelo, Gastòn E.; Kretzler, Matthias.

In: Kidney International, Vol. 83, No. 4, 04.2013, p. 749-756.

Research output: Contribution to journalArticle

Gadegbeku, CA, Gipson, DS, Holzman, LB, Ojo, AO, Song, PXK, Barisoni, L, Sampson, MG, Kopp, JB, Lemley, KV, Nelson, PJ, Lienczewski, CC, Adler, SG, Appel, GB, Cattran, DC, Choi, MJ, Contreras, G, Dell, KM, Fervenza, FC, Gibson, KL, Greenbaum, LA, Hernandez, JD, Hewitt, SM, Hingorani, SR, Hladunewich, M, Hogan, MC, Hogan, SL, Kaskel, FJ, Lieske, JC, Meyers, KEC, Nachman, PH, Nast, CC, Neu, AM, Reich, HN, Sedor, JR, Sethna, CB, Trachtman, H, Tuttle, KR, Zhdanova, O, Zilleruelo, GE & Kretzler, M 2013, 'Design of the nephrotic syndrome study network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach', Kidney International, vol. 83, no. 4, pp. 749-756. https://doi.org/10.1038/ki.2012.428
Gadegbeku, Crystal A. ; Gipson, Debbie S. ; Holzman, Lawrence B. ; Ojo, Akinlolu O. ; Song, Peter X K ; Barisoni, Laura ; Sampson, Matthew G. ; Kopp, Jeffrey B. ; Lemley, Kevin V. ; Nelson, Peter J. ; Lienczewski, Chrysta C. ; Adler, Sharon G. ; Appel, Gerald B. ; Cattran, Daniel C. ; Choi, Michael J. ; Contreras, Gabriel ; Dell, Katherine M. ; Fervenza, Fernando C. ; Gibson, Keisha L. ; Greenbaum, Larry A. ; Hernandez, Joel D. ; Hewitt, Stephen M. ; Hingorani, Sangeeta R. ; Hladunewich, Michelle ; Hogan, Marie C. ; Hogan, Susan L. ; Kaskel, Frederick J. ; Lieske, John C. ; Meyers, Kevin E C ; Nachman, Patrick H. ; Nast, Cynthia C. ; Neu, Alicia M. ; Reich, Heather N. ; Sedor, John R. ; Sethna, Christine B. ; Trachtman, Howard ; Tuttle, Katherine R. ; Zhdanova, Olga ; Zilleruelo, Gastòn E. ; Kretzler, Matthias. / Design of the nephrotic syndrome study network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. In: Kidney International. 2013 ; Vol. 83, No. 4. pp. 749-756.
@article{892f59551be64000b1ff35adde489c78,
title = "Design of the nephrotic syndrome study network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach",
abstract = "The Nephrotic Syndrome Study Network (NEPTUNE) is a North American multicenter collaborative consortium established to develop a translational research infrastructure for nephrotic syndrome. This includes a longitudinal observational cohort study, a pilot and ancillary study program, a training program, and a patient contact registry. NEPTUNE will enroll 450 adults and children with minimal change disease, focal segmental glomerulosclerosis, and membranous nephropathy for detailed clinical, histopathological, and molecular phenotyping at the time of clinically indicated renal biopsy. Initial visits will include an extensive clinical history, physical examination, collection of urine, blood and renal tissue samples, and assessments of quality of life and patient-reported outcomes. Follow-up history, physical measures, urine and blood samples, and questionnaires will be obtained every 4 months in the first year and biannually, thereafter. Molecular profiles and gene expression data will be linked to phenotypic, genetic, and digitalized histological data for comprehensive analyses using systems biology approaches. Analytical strategies were designed to transform descriptive information to mechanistic disease classification for nephrotic syndrome and to identify clinical, histological, and genomic disease predictors. Thus, understanding the complexity of the disease pathogenesis will guide further investigation for targeted therapeutic strategies.",
keywords = "clinical trial, focal segmental glomerulosclerosis, membranous nephropathy, nephrotic syndrome",
author = "Gadegbeku, {Crystal A.} and Gipson, {Debbie S.} and Holzman, {Lawrence B.} and Ojo, {Akinlolu O.} and Song, {Peter X K} and Laura Barisoni and Sampson, {Matthew G.} and Kopp, {Jeffrey B.} and Lemley, {Kevin V.} and Nelson, {Peter J.} and Lienczewski, {Chrysta C.} and Adler, {Sharon G.} and Appel, {Gerald B.} and Cattran, {Daniel C.} and Choi, {Michael J.} and Gabriel Contreras and Dell, {Katherine M.} and Fervenza, {Fernando C.} and Gibson, {Keisha L.} and Greenbaum, {Larry A.} and Hernandez, {Joel D.} and Hewitt, {Stephen M.} and Hingorani, {Sangeeta R.} and Michelle Hladunewich and Hogan, {Marie C.} and Hogan, {Susan L.} and Kaskel, {Frederick J.} and Lieske, {John C.} and Meyers, {Kevin E C} and Nachman, {Patrick H.} and Nast, {Cynthia C.} and Neu, {Alicia M.} and Reich, {Heather N.} and Sedor, {John R.} and Sethna, {Christine B.} and Howard Trachtman and Tuttle, {Katherine R.} and Olga Zhdanova and Zilleruelo, {Gast{\`o}n E.} and Matthias Kretzler",
year = "2013",
month = "4",
doi = "10.1038/ki.2012.428",
language = "English (US)",
volume = "83",
pages = "749--756",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Design of the nephrotic syndrome study network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach

AU - Gadegbeku, Crystal A.

AU - Gipson, Debbie S.

AU - Holzman, Lawrence B.

AU - Ojo, Akinlolu O.

AU - Song, Peter X K

AU - Barisoni, Laura

AU - Sampson, Matthew G.

AU - Kopp, Jeffrey B.

AU - Lemley, Kevin V.

AU - Nelson, Peter J.

AU - Lienczewski, Chrysta C.

AU - Adler, Sharon G.

AU - Appel, Gerald B.

AU - Cattran, Daniel C.

AU - Choi, Michael J.

AU - Contreras, Gabriel

AU - Dell, Katherine M.

AU - Fervenza, Fernando C.

AU - Gibson, Keisha L.

AU - Greenbaum, Larry A.

AU - Hernandez, Joel D.

AU - Hewitt, Stephen M.

AU - Hingorani, Sangeeta R.

AU - Hladunewich, Michelle

AU - Hogan, Marie C.

AU - Hogan, Susan L.

AU - Kaskel, Frederick J.

AU - Lieske, John C.

AU - Meyers, Kevin E C

AU - Nachman, Patrick H.

AU - Nast, Cynthia C.

AU - Neu, Alicia M.

AU - Reich, Heather N.

AU - Sedor, John R.

AU - Sethna, Christine B.

AU - Trachtman, Howard

AU - Tuttle, Katherine R.

AU - Zhdanova, Olga

AU - Zilleruelo, Gastòn E.

AU - Kretzler, Matthias

PY - 2013/4

Y1 - 2013/4

N2 - The Nephrotic Syndrome Study Network (NEPTUNE) is a North American multicenter collaborative consortium established to develop a translational research infrastructure for nephrotic syndrome. This includes a longitudinal observational cohort study, a pilot and ancillary study program, a training program, and a patient contact registry. NEPTUNE will enroll 450 adults and children with minimal change disease, focal segmental glomerulosclerosis, and membranous nephropathy for detailed clinical, histopathological, and molecular phenotyping at the time of clinically indicated renal biopsy. Initial visits will include an extensive clinical history, physical examination, collection of urine, blood and renal tissue samples, and assessments of quality of life and patient-reported outcomes. Follow-up history, physical measures, urine and blood samples, and questionnaires will be obtained every 4 months in the first year and biannually, thereafter. Molecular profiles and gene expression data will be linked to phenotypic, genetic, and digitalized histological data for comprehensive analyses using systems biology approaches. Analytical strategies were designed to transform descriptive information to mechanistic disease classification for nephrotic syndrome and to identify clinical, histological, and genomic disease predictors. Thus, understanding the complexity of the disease pathogenesis will guide further investigation for targeted therapeutic strategies.

AB - The Nephrotic Syndrome Study Network (NEPTUNE) is a North American multicenter collaborative consortium established to develop a translational research infrastructure for nephrotic syndrome. This includes a longitudinal observational cohort study, a pilot and ancillary study program, a training program, and a patient contact registry. NEPTUNE will enroll 450 adults and children with minimal change disease, focal segmental glomerulosclerosis, and membranous nephropathy for detailed clinical, histopathological, and molecular phenotyping at the time of clinically indicated renal biopsy. Initial visits will include an extensive clinical history, physical examination, collection of urine, blood and renal tissue samples, and assessments of quality of life and patient-reported outcomes. Follow-up history, physical measures, urine and blood samples, and questionnaires will be obtained every 4 months in the first year and biannually, thereafter. Molecular profiles and gene expression data will be linked to phenotypic, genetic, and digitalized histological data for comprehensive analyses using systems biology approaches. Analytical strategies were designed to transform descriptive information to mechanistic disease classification for nephrotic syndrome and to identify clinical, histological, and genomic disease predictors. Thus, understanding the complexity of the disease pathogenesis will guide further investigation for targeted therapeutic strategies.

KW - clinical trial

KW - focal segmental glomerulosclerosis

KW - membranous nephropathy

KW - nephrotic syndrome

UR - http://www.scopus.com/inward/record.url?scp=84875701332&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875701332&partnerID=8YFLogxK

U2 - 10.1038/ki.2012.428

DO - 10.1038/ki.2012.428

M3 - Article

VL - 83

SP - 749

EP - 756

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 4

ER -