Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor

Seung Yub Lee, Fubo Liang, Xiao Ling Guo, Laiping Xie, Sean M. Cahill, Michael Blumenstein, Heyi Yang, David S. Lawrence, Zhong Yin Zhang

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

(Figure Presented) Ricin, diphtheria toxin, and other cytotoxic proteins are two-component systems which contain a carrier protein that biochemically silences the activity of the appended "warhead" protein until it is delivered into the cell. A cell-penetrating peptide (CPP) has been used in an analogous fashion (see picture) to suppress the activity of a PTP1B inhibitor that becomes activated by cleavage of the disulfide bridge upon cellular entry.

Original languageEnglish (US)
Pages (from-to)4242-4244
Number of pages3
JournalAngewandte Chemie - International Edition
Volume44
Issue number27
DOIs
StatePublished - Jul 4 2005

Keywords

  • Drug delivery
  • Inhibitors
  • Peptides
  • Prodrugs
  • Signal transduction

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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