(Figure Presented) Ricin, diphtheria toxin, and other cytotoxic proteins are two-component systems which contain a carrier protein that biochemically silences the activity of the appended "warhead" protein until it is delivered into the cell. A cell-penetrating peptide (CPP) has been used in an analogous fashion (see picture) to suppress the activity of a PTP1B inhibitor that becomes activated by cleavage of the disulfide bridge upon cellular entry.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Jul 4 2005|
- Drug delivery
- Signal transduction
ASJC Scopus subject areas