Design and methods of the Chronic Kidney Disease in Children (CKiD) prospective cohort study.

Susan L. Furth, Stephen R. Cole, Marva Moxey-Mims, Frederick J. Kaskel, Robert Mak, George Schwartz, Craig Wong, Alvaro Muñoz, Bradley A. Warady

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

An estimated 650,000 Americans will have ESRD by 2010. Young adults with kidney failure often develop progressive chronic kidney disease (CKD) in childhood and adolescence. The Chronic Kidney Disease in Children (CKiD) prospective cohort study of 540 children aged 1 to 16 yr and have estimated GFR between 30 and 75 ml/min per 1.73 m2 was established to identify novel risk factors for CKD progression; the impact of kidney function decline on growth, cognition, and behavior; and the evolution of cardiovascular disease risk factors. Annually, a physical examination documenting height, weight, Tanner stage, and standardized BP is conducted, and cognitive function, quality of life, nutritional, and behavioral questionnaires are completed by the parent or the child. Samples of serum, plasma, urine, hair, and fingernail clippings are stored in biosamples and genetics repositories. GFR is measured annually for 2 yr, then every other year using iohexol, HPLC creatinine, and cystatin C. Using age, gender, and serial measurements of Tanner stage, height, and creatinine, compared with iohexol GFR, a formula to estimate GFR that will improve on traditional pediatric GFR estimating equations when applied longitudinally is expected to be developed. Every other year, echocardiography and ambulatory BP monitoring will assess risk for cardiovascular disease. The primary outcome is the rate of decline of GFR. The CKiD study will be the largest North American multicenter study of pediatric CKD.

Original languageEnglish (US)
Pages (from-to)1006-1015
Number of pages10
JournalClinical journal of the American Society of Nephrology : CJASN
Volume1
Issue number5
DOIs
StatePublished - Sep 2006
Externally publishedYes

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Chronic Renal Insufficiency
Cohort Studies
Prospective Studies
Iohexol
Cognition
Creatinine
Cardiovascular Diseases
Pediatrics
Cystatin C
Ambulatory Monitoring
Nails
Hair
Multicenter Studies
Physical Examination
Chronic Kidney Failure
Renal Insufficiency
Echocardiography
Disease Progression
Young Adult
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Design and methods of the Chronic Kidney Disease in Children (CKiD) prospective cohort study. / Furth, Susan L.; Cole, Stephen R.; Moxey-Mims, Marva; Kaskel, Frederick J.; Mak, Robert; Schwartz, George; Wong, Craig; Muñoz, Alvaro; Warady, Bradley A.

In: Clinical journal of the American Society of Nephrology : CJASN, Vol. 1, No. 5, 09.2006, p. 1006-1015.

Research output: Contribution to journalArticle

Furth, Susan L. ; Cole, Stephen R. ; Moxey-Mims, Marva ; Kaskel, Frederick J. ; Mak, Robert ; Schwartz, George ; Wong, Craig ; Muñoz, Alvaro ; Warady, Bradley A. / Design and methods of the Chronic Kidney Disease in Children (CKiD) prospective cohort study. In: Clinical journal of the American Society of Nephrology : CJASN. 2006 ; Vol. 1, No. 5. pp. 1006-1015.
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