TY - JOUR
T1 - Design and evaluation of a passive alcove-based microfluidic mixer
AU - Egawa, Tsuyoshi
AU - Durand, Jorge L.
AU - Hayden, Eric Y.
AU - Rousseau, Denis L.
AU - Yeh, Syun Ru
PY - 2009/2/15
Y1 - 2009/2/15
N2 - A novel passive microfluidic silicon mixer has been designed, optimized and fabricated. The architecture of the mixer consists of a simple "T" junction, made up by a 20 μm wide by 82 μm deep channel, followed by three repeats of an alcove, each with a triangular obstruction, arranged in a zigzag fashion. Numerical simulations were employed to optimize the geometry, particularly the dimensions of the alcoves, the relative orientation and the spacing between them, and the degree of intrusion associated with them. The simulation results demonstrate that chaotic flow due to recirculation within the alcoves results in transverse velocity that promotes effective fluid mixing. The microfluidic mixer with the simulation-optimized geometry was fabricated with photolithographic techniques and characterized by optical imaging, fluorescence, and Raman microscope spectroscopy. At a sample flow rate of 20 μL/s, the mixer exhibits a short mixing deadtime of ∼22 μs and a high mixing efficiency under both low and high viscosity conditions. The alcove-based microfluidic silicon mixer offers unique advantages for its short deadtime and slow sample consumption rate. In addition, it provides a valuable component for laboratory-on-a-chip applications for its ease of development into multiple networks for massively parallel analytical processes.
AB - A novel passive microfluidic silicon mixer has been designed, optimized and fabricated. The architecture of the mixer consists of a simple "T" junction, made up by a 20 μm wide by 82 μm deep channel, followed by three repeats of an alcove, each with a triangular obstruction, arranged in a zigzag fashion. Numerical simulations were employed to optimize the geometry, particularly the dimensions of the alcoves, the relative orientation and the spacing between them, and the degree of intrusion associated with them. The simulation results demonstrate that chaotic flow due to recirculation within the alcoves results in transverse velocity that promotes effective fluid mixing. The microfluidic mixer with the simulation-optimized geometry was fabricated with photolithographic techniques and characterized by optical imaging, fluorescence, and Raman microscope spectroscopy. At a sample flow rate of 20 μL/s, the mixer exhibits a short mixing deadtime of ∼22 μs and a high mixing efficiency under both low and high viscosity conditions. The alcove-based microfluidic silicon mixer offers unique advantages for its short deadtime and slow sample consumption rate. In addition, it provides a valuable component for laboratory-on-a-chip applications for its ease of development into multiple networks for massively parallel analytical processes.
UR - http://www.scopus.com/inward/record.url?scp=63649116693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63649116693&partnerID=8YFLogxK
U2 - 10.1021/ac802410g
DO - 10.1021/ac802410g
M3 - Article
C2 - 19140669
AN - SCOPUS:63649116693
SN - 0003-2700
VL - 81
SP - 1622
EP - 1627
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 4
ER -