Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography

Roman V. Kuranov; Jinze Qiu; Austin B. Mcelroy; Arnold Estrada; Anthony Salvaggio; Jeffrey Kiel; Andrew K. Dunn; Timothy Q. Duong; Thomas E. Milner

doi:10.1364/BOE.2.000491

Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography

Roman V. Kuranov, Jinze Qiu, Austin B. Mcelroy, Arnold Estrada, Anthony Salvaggio, Jeffrey Kiel, Andrew K. Dunn, Timothy Q. Duong, Thomas E. Milner

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO₂) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photo thermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO₂ levels in a blood vessel phantom. DWP OCT SaO₂ is linearly correlated with blood-gas SaO₂ measurements. We demonstrate 6.3% precision in SaO₂ levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO₂ levels measured with DWP-OCT are identified and characterized.

Original language	English (US)
Pages (from-to)	491-504
Number of pages	14
Journal	Biomedical Optics Express
Volume	2
Issue number	3
DOIs	https://doi.org/10.1364/BOE.2.000491
State	Published - Mar 1 2011
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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title = "Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography",

abstract = "Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO2) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photo thermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO2 levels in a blood vessel phantom. DWP OCT SaO2 is linearly correlated with blood-gas SaO2 measurements. We demonstrate 6.3% precision in SaO2 levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO2 levels measured with DWP-OCT are identified and characterized.",

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AU - Kuranov, Roman V.

AU - Qiu, Jinze

AU - Mcelroy, Austin B.

AU - Estrada, Arnold

AU - Salvaggio, Anthony

AU - Kiel, Jeffrey

AU - Dunn, Andrew K.

AU - Duong, Timothy Q.

AU - Milner, Thomas E.

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AB - Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO2) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photo thermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO2 levels in a blood vessel phantom. DWP OCT SaO2 is linearly correlated with blood-gas SaO2 measurements. We demonstrate 6.3% precision in SaO2 levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO2 levels measured with DWP-OCT are identified and characterized.

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Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography

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