Depression is an early disease manifestation in lupus-prone MRL/lpr mice

Hua Xin Gao; Sean R. Campbell; Min Hui Cui; Pu Zong; Jong hee-Hwang; Maria Gulinello; Chaim Putterman

doi:10.1016/j.jneuroim.2008.11.009

Depression is an early disease manifestation in lupus-prone MRL/lpr mice

Hua Xin Gao, Sean R. Campbell, Min Hui Cui, Pu Zong, Jong hee-Hwang, Maria Gulinello, Chaim Putterman

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.

Original language	English (US)
Pages (from-to)	45-56
Number of pages	12
Journal	Journal of Neuroimmunology
Volume	207
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2008.11.009
State	Published - Feb 15 2009

Keywords

Anti-DNA antibodies
Depression
Neuropsychiatric lupus
Systemic Lupus Erythematosus

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2008.11.009

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title = "Depression is an early disease manifestation in lupus-prone MRL/lpr mice",

abstract = "Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.",

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AU - Gao, Hua Xin

AU - Campbell, Sean R.

AU - Cui, Min Hui

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AU - hee-Hwang, Jong

AU - Gulinello, Maria

AU - Putterman, Chaim

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AB - Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.

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