Abstract
Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 45-56 |
| Number of pages | 12 |
| Journal | Journal of Neuroimmunology |
| Volume | 207 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Feb 15 2009 |
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Keywords
- Anti-DNA antibodies
- Depression
- Neuropsychiatric lupus
- Systemic Lupus Erythematosus
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Depression is an early disease manifestation in lupus-prone MRL/lpr mice. / Gao, Hua Xin; Campbell, Sean R.; Cui, Min-Hui; Zong, Pu; hee-Hwang, Jong; Gulinello, Maria E.; Putterman, Chaim.
In: Journal of Neuroimmunology, Vol. 207, No. 1-2, 15.02.2009, p. 45-56.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depression is an early disease manifestation in lupus-prone MRL/lpr mice
AU - Gao, Hua Xin
AU - Campbell, Sean R.
AU - Cui, Min-Hui
AU - Zong, Pu
AU - hee-Hwang, Jong
AU - Gulinello, Maria E.
AU - Putterman, Chaim
PY - 2009/2/15
Y1 - 2009/2/15
N2 - Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.
AB - Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.
KW - Anti-DNA antibodies
KW - Depression
KW - Neuropsychiatric lupus
KW - Systemic Lupus Erythematosus
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UR - http://www.scopus.com/inward/citedby.url?scp=60149109686&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2008.11.009
DO - 10.1016/j.jneuroim.2008.11.009
M3 - Article
VL - 207
SP - 45
EP - 56
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -