TY - JOUR
T1 - Depression is an early disease manifestation in lupus-prone MRL/lpr mice
AU - Gao, Hua Xin
AU - Campbell, Sean R.
AU - Cui, Min Hui
AU - Zong, Pu
AU - hee-Hwang, Jong
AU - Gulinello, Maria
AU - Putterman, Chaim
PY - 2009/2/15
Y1 - 2009/2/15
N2 - Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.
AB - Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.
KW - Anti-DNA antibodies
KW - Depression
KW - Neuropsychiatric lupus
KW - Systemic Lupus Erythematosus
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U2 - 10.1016/j.jneuroim.2008.11.009
DO - 10.1016/j.jneuroim.2008.11.009
M3 - Article
C2 - 19121871
AN - SCOPUS:60149109686
SN - 0165-5728
VL - 207
SP - 45
EP - 56
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -