Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia

Dimitris N. Kiosses, Paul B. Rosenberg, Amanda McGovern, Pasquale Fonzetti, Hana Zaydens, George S. Alexopoulos

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Depression is prevalent in dementia and contributes to poor outcomes for patients and their families. Antidepressants have limited efficacy in older adults with major depression and dementia, and psychosocial interventions are under-investigated. Objective: To examine the course, predictors and moderators of depression and suicidal ideation during 12 weeks of homedelivered Problem Adaptation Therapy (PATH) versus Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in 39 older adults with major depression and dementia. Methods: Thirty-nine older adults with major depression, mild or moderate dementia, and disability participated in a randomized controlled trial that compared the efficacy of PATH versus ST-CI. Depression and suicidal ideation were assessed with Cornell Scale for Depression in Dementia Total Score and Suicide Item. Results: PATH participants had significantly greater reduction in depression than ST-CI participants over 12 weeks of treatment. PATH participants with high social support had the greatest reduction in depression. Both treatments had comparable reduction in suicidal ideation. Conclusion: PATH is more effective in reducing depression in older adults with major depression and dementia compared to ST-CI. These results are clinically significant as antidepressants have limited efficacy in this population. Home-delivered psychosocial treatments may reduce suicidal ideation in this population.

Original languageEnglish (US)
Pages (from-to)453-462
Number of pages10
JournalJournal of Alzheimer's Disease
Volume48
Issue number2
DOIs
StatePublished - Sep 9 2015
Externally publishedYes

Fingerprint

Suicidal Ideation
Dementia
Depression
Therapeutics
Antidepressive Agents
Social Support
Suicide
Population
Randomized Controlled Trials

Keywords

  • Dementia
  • depression
  • psychosocial interventions
  • social support
  • suicidal ideation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia. / Kiosses, Dimitris N.; Rosenberg, Paul B.; McGovern, Amanda; Fonzetti, Pasquale; Zaydens, Hana; Alexopoulos, George S.

In: Journal of Alzheimer's Disease, Vol. 48, No. 2, 09.09.2015, p. 453-462.

Research output: Contribution to journalArticle

Kiosses, Dimitris N. ; Rosenberg, Paul B. ; McGovern, Amanda ; Fonzetti, Pasquale ; Zaydens, Hana ; Alexopoulos, George S. / Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia. In: Journal of Alzheimer's Disease. 2015 ; Vol. 48, No. 2. pp. 453-462.
@article{5402e254724f4814920cc318d33d530e,
title = "Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia",
abstract = "Background: Depression is prevalent in dementia and contributes to poor outcomes for patients and their families. Antidepressants have limited efficacy in older adults with major depression and dementia, and psychosocial interventions are under-investigated. Objective: To examine the course, predictors and moderators of depression and suicidal ideation during 12 weeks of homedelivered Problem Adaptation Therapy (PATH) versus Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in 39 older adults with major depression and dementia. Methods: Thirty-nine older adults with major depression, mild or moderate dementia, and disability participated in a randomized controlled trial that compared the efficacy of PATH versus ST-CI. Depression and suicidal ideation were assessed with Cornell Scale for Depression in Dementia Total Score and Suicide Item. Results: PATH participants had significantly greater reduction in depression than ST-CI participants over 12 weeks of treatment. PATH participants with high social support had the greatest reduction in depression. Both treatments had comparable reduction in suicidal ideation. Conclusion: PATH is more effective in reducing depression in older adults with major depression and dementia compared to ST-CI. These results are clinically significant as antidepressants have limited efficacy in this population. Home-delivered psychosocial treatments may reduce suicidal ideation in this population.",
keywords = "Dementia, depression, psychosocial interventions, social support, suicidal ideation",
author = "Kiosses, {Dimitris N.} and Rosenberg, {Paul B.} and Amanda McGovern and Pasquale Fonzetti and Hana Zaydens and Alexopoulos, {George S.}",
year = "2015",
month = "9",
day = "9",
doi = "10.3233/JAD-150200",
language = "English (US)",
volume = "48",
pages = "453--462",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "2",

}

TY - JOUR

T1 - Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia

AU - Kiosses, Dimitris N.

AU - Rosenberg, Paul B.

AU - McGovern, Amanda

AU - Fonzetti, Pasquale

AU - Zaydens, Hana

AU - Alexopoulos, George S.

PY - 2015/9/9

Y1 - 2015/9/9

N2 - Background: Depression is prevalent in dementia and contributes to poor outcomes for patients and their families. Antidepressants have limited efficacy in older adults with major depression and dementia, and psychosocial interventions are under-investigated. Objective: To examine the course, predictors and moderators of depression and suicidal ideation during 12 weeks of homedelivered Problem Adaptation Therapy (PATH) versus Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in 39 older adults with major depression and dementia. Methods: Thirty-nine older adults with major depression, mild or moderate dementia, and disability participated in a randomized controlled trial that compared the efficacy of PATH versus ST-CI. Depression and suicidal ideation were assessed with Cornell Scale for Depression in Dementia Total Score and Suicide Item. Results: PATH participants had significantly greater reduction in depression than ST-CI participants over 12 weeks of treatment. PATH participants with high social support had the greatest reduction in depression. Both treatments had comparable reduction in suicidal ideation. Conclusion: PATH is more effective in reducing depression in older adults with major depression and dementia compared to ST-CI. These results are clinically significant as antidepressants have limited efficacy in this population. Home-delivered psychosocial treatments may reduce suicidal ideation in this population.

AB - Background: Depression is prevalent in dementia and contributes to poor outcomes for patients and their families. Antidepressants have limited efficacy in older adults with major depression and dementia, and psychosocial interventions are under-investigated. Objective: To examine the course, predictors and moderators of depression and suicidal ideation during 12 weeks of homedelivered Problem Adaptation Therapy (PATH) versus Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in 39 older adults with major depression and dementia. Methods: Thirty-nine older adults with major depression, mild or moderate dementia, and disability participated in a randomized controlled trial that compared the efficacy of PATH versus ST-CI. Depression and suicidal ideation were assessed with Cornell Scale for Depression in Dementia Total Score and Suicide Item. Results: PATH participants had significantly greater reduction in depression than ST-CI participants over 12 weeks of treatment. PATH participants with high social support had the greatest reduction in depression. Both treatments had comparable reduction in suicidal ideation. Conclusion: PATH is more effective in reducing depression in older adults with major depression and dementia compared to ST-CI. These results are clinically significant as antidepressants have limited efficacy in this population. Home-delivered psychosocial treatments may reduce suicidal ideation in this population.

KW - Dementia

KW - depression

KW - psychosocial interventions

KW - social support

KW - suicidal ideation

UR - http://www.scopus.com/inward/record.url?scp=84941266658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941266658&partnerID=8YFLogxK

U2 - 10.3233/JAD-150200

DO - 10.3233/JAD-150200

M3 - Article

C2 - 26402009

AN - SCOPUS:84941266658

VL - 48

SP - 453

EP - 462

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 2

ER -