Depolarization-induced suppression of spontaneous release in the avian midbrain

Mario Alexander Penzo, Jose L. Pena

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Spontaneous neurotransmitter release has been considered synaptic noise for decades. Recent work, however, suggests that synaptic events arising from action potential (AP)-independent neurotransmitter release contribute to synaptic function in a manner qualitatively different from AP-dependent release. We investigated the effect of somatic depolarization on spontaneous neurotransmitter release in neurons of the external portion (EX) of the chicken inferior colliculus. We found this manipulation affects spontaneous but not AP-dependent release onto EX neurons in a retrograde manner. This depolarization-induced suppression of spontaneous release requires activation of NMDA receptors on the presynaptic cell and postsynaptic calcium-dependent vesicle fusion. These results show a novel form of plasticity that allows the postsynaptic cell to selectively modulate spontaneous neurotransmitter release of its afferent inputs.

Original languageEnglish (US)
Pages (from-to)3602-3609
Number of pages8
JournalJournal of Neuroscience
Volume31
Issue number10
DOIs
StatePublished - Mar 9 2011

Fingerprint

Mesencephalon
Neurotransmitter Agents
Action Potentials
Neurons
Inferior Colliculi
N-Methyl-D-Aspartate Receptors
Noise
Chickens
Calcium

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Depolarization-induced suppression of spontaneous release in the avian midbrain. / Penzo, Mario Alexander; Pena, Jose L.

In: Journal of Neuroscience, Vol. 31, No. 10, 09.03.2011, p. 3602-3609.

Research output: Contribution to journalArticle

@article{9fce5c42ab9a4914954a988c3be01519,
title = "Depolarization-induced suppression of spontaneous release in the avian midbrain",
abstract = "Spontaneous neurotransmitter release has been considered synaptic noise for decades. Recent work, however, suggests that synaptic events arising from action potential (AP)-independent neurotransmitter release contribute to synaptic function in a manner qualitatively different from AP-dependent release. We investigated the effect of somatic depolarization on spontaneous neurotransmitter release in neurons of the external portion (EX) of the chicken inferior colliculus. We found this manipulation affects spontaneous but not AP-dependent release onto EX neurons in a retrograde manner. This depolarization-induced suppression of spontaneous release requires activation of NMDA receptors on the presynaptic cell and postsynaptic calcium-dependent vesicle fusion. These results show a novel form of plasticity that allows the postsynaptic cell to selectively modulate spontaneous neurotransmitter release of its afferent inputs.",
author = "Penzo, {Mario Alexander} and Pena, {Jose L.}",
year = "2011",
month = "3",
day = "9",
doi = "10.1523/JNEUROSCI.6388-10.2011",
language = "English (US)",
volume = "31",
pages = "3602--3609",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "10",

}

TY - JOUR

T1 - Depolarization-induced suppression of spontaneous release in the avian midbrain

AU - Penzo, Mario Alexander

AU - Pena, Jose L.

PY - 2011/3/9

Y1 - 2011/3/9

N2 - Spontaneous neurotransmitter release has been considered synaptic noise for decades. Recent work, however, suggests that synaptic events arising from action potential (AP)-independent neurotransmitter release contribute to synaptic function in a manner qualitatively different from AP-dependent release. We investigated the effect of somatic depolarization on spontaneous neurotransmitter release in neurons of the external portion (EX) of the chicken inferior colliculus. We found this manipulation affects spontaneous but not AP-dependent release onto EX neurons in a retrograde manner. This depolarization-induced suppression of spontaneous release requires activation of NMDA receptors on the presynaptic cell and postsynaptic calcium-dependent vesicle fusion. These results show a novel form of plasticity that allows the postsynaptic cell to selectively modulate spontaneous neurotransmitter release of its afferent inputs.

AB - Spontaneous neurotransmitter release has been considered synaptic noise for decades. Recent work, however, suggests that synaptic events arising from action potential (AP)-independent neurotransmitter release contribute to synaptic function in a manner qualitatively different from AP-dependent release. We investigated the effect of somatic depolarization on spontaneous neurotransmitter release in neurons of the external portion (EX) of the chicken inferior colliculus. We found this manipulation affects spontaneous but not AP-dependent release onto EX neurons in a retrograde manner. This depolarization-induced suppression of spontaneous release requires activation of NMDA receptors on the presynaptic cell and postsynaptic calcium-dependent vesicle fusion. These results show a novel form of plasticity that allows the postsynaptic cell to selectively modulate spontaneous neurotransmitter release of its afferent inputs.

UR - http://www.scopus.com/inward/record.url?scp=79952424475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952424475&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.6388-10.2011

DO - 10.1523/JNEUROSCI.6388-10.2011

M3 - Article

C2 - 21389216

AN - SCOPUS:79952424475

VL - 31

SP - 3602

EP - 3609

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 10

ER -