TY - JOUR
T1 - Depolarization-induced suppression of spontaneous release in the avian midbrain
AU - Penzo, Mario Alexander
AU - Peña, José Luis
PY - 2011/3/9
Y1 - 2011/3/9
N2 - Spontaneous neurotransmitter release has been considered synaptic noise for decades. Recent work, however, suggests that synaptic events arising from action potential (AP)-independent neurotransmitter release contribute to synaptic function in a manner qualitatively different from AP-dependent release. We investigated the effect of somatic depolarization on spontaneous neurotransmitter release in neurons of the external portion (EX) of the chicken inferior colliculus. We found this manipulation affects spontaneous but not AP-dependent release onto EX neurons in a retrograde manner. This depolarization-induced suppression of spontaneous release requires activation of NMDA receptors on the presynaptic cell and postsynaptic calcium-dependent vesicle fusion. These results show a novel form of plasticity that allows the postsynaptic cell to selectively modulate spontaneous neurotransmitter release of its afferent inputs.
AB - Spontaneous neurotransmitter release has been considered synaptic noise for decades. Recent work, however, suggests that synaptic events arising from action potential (AP)-independent neurotransmitter release contribute to synaptic function in a manner qualitatively different from AP-dependent release. We investigated the effect of somatic depolarization on spontaneous neurotransmitter release in neurons of the external portion (EX) of the chicken inferior colliculus. We found this manipulation affects spontaneous but not AP-dependent release onto EX neurons in a retrograde manner. This depolarization-induced suppression of spontaneous release requires activation of NMDA receptors on the presynaptic cell and postsynaptic calcium-dependent vesicle fusion. These results show a novel form of plasticity that allows the postsynaptic cell to selectively modulate spontaneous neurotransmitter release of its afferent inputs.
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U2 - 10.1523/JNEUROSCI.6388-10.2011
DO - 10.1523/JNEUROSCI.6388-10.2011
M3 - Article
C2 - 21389216
AN - SCOPUS:79952424475
SN - 0270-6474
VL - 31
SP - 3602
EP - 3609
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 10
ER -