Density-dependent lectin-glycan interactions as a paradigm for conditional regulation by posttranslational modifications

James W. Dennis, C. Fred Brewer

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

Mice with null mutations in specific Golgi glycosyltrans-ferases show evidence of glycan compensation where missing carbohydrate epitopes are found on biosyntheti-cally related structures. Repetitive saccharide sequences within the larger glycan structures are functional epitopes recognized by animal lectins. These studies provide the first in vivo support for the existence of a feedback system that maintains and regulates glycan epitope density in cells. Receptor regulation by lectin-glycan interactions and the Golgi provides a mechanism for the adaptation of cell surface receptors and solute transporters in response to environmental cues and intracellular signaling. We suggest that other posttranslational modification systems might have similar conditional features regulated by density-dependent ligand-epitope interactions.

Original languageEnglish (US)
Pages (from-to)913-920
Number of pages8
JournalMolecular and Cellular Proteomics
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 1 2013

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology

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