Denosologization of biological psychiatry or the specificity of 5-HT disturbances in psychiatric disorders

Herman M. van Praag, Rene S. Kahn, Gregory M. Asnis, Scott Wetzler, Serena L. Brown, Avraham Bleich, Martin L. Korn

Research output: Contribution to journalArticle

203 Citations (Scopus)

Abstract

5-Hydroxytraptamine (5-HT) disorders have been reported to occur in a variety of psychiatric disorders. The situation has been called chaotic, the disturbances non-specific. We reject this viewpoint. 5-HT disturbances are non-specific only from a nosological/categorical viewpoint; they seem rather specific from a functional/dimensional point of view, correlating as they do with particular psychopathological dimensions, i.e. aggression-, anxiety- and possibly mood-disregulation, across diagnosis. The evolution of 5-HT research in psychiatry illustrates the importance of what we have called the functional approach, implying dissection of a given psychopathological syndrome in its component parts, i.e., the psychological dysfunctions, and searching for correlations between biological and psychological dysfunctions. The rigid preoccupation of biological psychiatry with the search for markets of disease entities has hampered progress. The functional approach should be incorporated in biological psychiatry, not as an alternative for the nosological approach but as its complement.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Affective Disorders
Volume13
Issue number1
DOIs
StatePublished - 1987

Fingerprint

Biological Psychiatry
Psychiatry
Psychology
Aggression
Dissection
Anxiety
Research

Keywords

  • 5-Hydroxytryptamine
  • Aggression
  • Anxiety
  • Depressive disorder
  • Mood
  • Psychiatric disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Denosologization of biological psychiatry or the specificity of 5-HT disturbances in psychiatric disorders. / van Praag, Herman M.; Kahn, Rene S.; Asnis, Gregory M.; Wetzler, Scott; Brown, Serena L.; Bleich, Avraham; Korn, Martin L.

In: Journal of Affective Disorders, Vol. 13, No. 1, 1987, p. 1-8.

Research output: Contribution to journalArticle

van Praag, Herman M. ; Kahn, Rene S. ; Asnis, Gregory M. ; Wetzler, Scott ; Brown, Serena L. ; Bleich, Avraham ; Korn, Martin L. / Denosologization of biological psychiatry or the specificity of 5-HT disturbances in psychiatric disorders. In: Journal of Affective Disorders. 1987 ; Vol. 13, No. 1. pp. 1-8.
@article{113a14d9e85946da83026d9852a0b18c,
title = "Denosologization of biological psychiatry or the specificity of 5-HT disturbances in psychiatric disorders",
abstract = "5-Hydroxytraptamine (5-HT) disorders have been reported to occur in a variety of psychiatric disorders. The situation has been called chaotic, the disturbances non-specific. We reject this viewpoint. 5-HT disturbances are non-specific only from a nosological/categorical viewpoint; they seem rather specific from a functional/dimensional point of view, correlating as they do with particular psychopathological dimensions, i.e. aggression-, anxiety- and possibly mood-disregulation, across diagnosis. The evolution of 5-HT research in psychiatry illustrates the importance of what we have called the functional approach, implying dissection of a given psychopathological syndrome in its component parts, i.e., the psychological dysfunctions, and searching for correlations between biological and psychological dysfunctions. The rigid preoccupation of biological psychiatry with the search for markets of disease entities has hampered progress. The functional approach should be incorporated in biological psychiatry, not as an alternative for the nosological approach but as its complement.",
keywords = "5-Hydroxytryptamine, Aggression, Anxiety, Depressive disorder, Mood, Psychiatric disorder",
author = "{van Praag}, {Herman M.} and Kahn, {Rene S.} and Asnis, {Gregory M.} and Scott Wetzler and Brown, {Serena L.} and Avraham Bleich and Korn, {Martin L.}",
year = "1987",
doi = "10.1016/0165-0327(87)90067-X",
language = "English (US)",
volume = "13",
pages = "1--8",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Denosologization of biological psychiatry or the specificity of 5-HT disturbances in psychiatric disorders

AU - van Praag, Herman M.

AU - Kahn, Rene S.

AU - Asnis, Gregory M.

AU - Wetzler, Scott

AU - Brown, Serena L.

AU - Bleich, Avraham

AU - Korn, Martin L.

PY - 1987

Y1 - 1987

N2 - 5-Hydroxytraptamine (5-HT) disorders have been reported to occur in a variety of psychiatric disorders. The situation has been called chaotic, the disturbances non-specific. We reject this viewpoint. 5-HT disturbances are non-specific only from a nosological/categorical viewpoint; they seem rather specific from a functional/dimensional point of view, correlating as they do with particular psychopathological dimensions, i.e. aggression-, anxiety- and possibly mood-disregulation, across diagnosis. The evolution of 5-HT research in psychiatry illustrates the importance of what we have called the functional approach, implying dissection of a given psychopathological syndrome in its component parts, i.e., the psychological dysfunctions, and searching for correlations between biological and psychological dysfunctions. The rigid preoccupation of biological psychiatry with the search for markets of disease entities has hampered progress. The functional approach should be incorporated in biological psychiatry, not as an alternative for the nosological approach but as its complement.

AB - 5-Hydroxytraptamine (5-HT) disorders have been reported to occur in a variety of psychiatric disorders. The situation has been called chaotic, the disturbances non-specific. We reject this viewpoint. 5-HT disturbances are non-specific only from a nosological/categorical viewpoint; they seem rather specific from a functional/dimensional point of view, correlating as they do with particular psychopathological dimensions, i.e. aggression-, anxiety- and possibly mood-disregulation, across diagnosis. The evolution of 5-HT research in psychiatry illustrates the importance of what we have called the functional approach, implying dissection of a given psychopathological syndrome in its component parts, i.e., the psychological dysfunctions, and searching for correlations between biological and psychological dysfunctions. The rigid preoccupation of biological psychiatry with the search for markets of disease entities has hampered progress. The functional approach should be incorporated in biological psychiatry, not as an alternative for the nosological approach but as its complement.

KW - 5-Hydroxytryptamine

KW - Aggression

KW - Anxiety

KW - Depressive disorder

KW - Mood

KW - Psychiatric disorder

UR - http://www.scopus.com/inward/record.url?scp=0023280351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023280351&partnerID=8YFLogxK

U2 - 10.1016/0165-0327(87)90067-X

DO - 10.1016/0165-0327(87)90067-X

M3 - Article

C2 - 2959695

AN - SCOPUS:0023280351

VL - 13

SP - 1

EP - 8

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1

ER -