TY - JOUR
T1 - Denosologization of biological psychiatry or the specificity of 5-HT disturbances in psychiatric disorders
AU - van Praag, Herman M.
AU - Kahn, Rene S.
AU - Asnis, Gregory M.
AU - Wetzler, Scott
AU - Brown, Serena L.
AU - Bleich, Avraham
AU - Korn, Martin L.
N1 - Funding Information:
The findings in GAD suggest that by decreasing 5-HT activity anxiety symptoms are ameliorated. This hypothesis is supported by data derived from the PD studies alluded to above. The effect of the indirect 5-HT agonists was reportedly biphasic (Kahn and Westenberg 1985). Initially the patients deteriorated, i.e., anxiety and panic increased. After 2-4 weeks the deterioration gradually gave way to improvement. This biphasic response has been tentatively ascribed to hypersensitivity of postsynaptic 5-HT receptors in (certain) anxiety states. Increasing 5-HT availability would initially worsen the condition, but due to down-regulation of the receptor system the therapeutic response would gradually ensue.
PY - 1987
Y1 - 1987
N2 - 5-Hydroxytraptamine (5-HT) disorders have been reported to occur in a variety of psychiatric disorders. The situation has been called chaotic, the disturbances non-specific. We reject this viewpoint. 5-HT disturbances are non-specific only from a nosological/categorical viewpoint; they seem rather specific from a functional/dimensional point of view, correlating as they do with particular psychopathological dimensions, i.e. aggression-, anxiety- and possibly mood-disregulation, across diagnosis. The evolution of 5-HT research in psychiatry illustrates the importance of what we have called the functional approach, implying dissection of a given psychopathological syndrome in its component parts, i.e., the psychological dysfunctions, and searching for correlations between biological and psychological dysfunctions. The rigid preoccupation of biological psychiatry with the search for markets of disease entities has hampered progress. The functional approach should be incorporated in biological psychiatry, not as an alternative for the nosological approach but as its complement.
AB - 5-Hydroxytraptamine (5-HT) disorders have been reported to occur in a variety of psychiatric disorders. The situation has been called chaotic, the disturbances non-specific. We reject this viewpoint. 5-HT disturbances are non-specific only from a nosological/categorical viewpoint; they seem rather specific from a functional/dimensional point of view, correlating as they do with particular psychopathological dimensions, i.e. aggression-, anxiety- and possibly mood-disregulation, across diagnosis. The evolution of 5-HT research in psychiatry illustrates the importance of what we have called the functional approach, implying dissection of a given psychopathological syndrome in its component parts, i.e., the psychological dysfunctions, and searching for correlations between biological and psychological dysfunctions. The rigid preoccupation of biological psychiatry with the search for markets of disease entities has hampered progress. The functional approach should be incorporated in biological psychiatry, not as an alternative for the nosological approach but as its complement.
KW - 5-Hydroxytryptamine
KW - Aggression
KW - Anxiety
KW - Depressive disorder
KW - Mood
KW - Psychiatric disorder
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U2 - 10.1016/0165-0327(87)90067-X
DO - 10.1016/0165-0327(87)90067-X
M3 - Review article
C2 - 2959695
AN - SCOPUS:0023280351
SN - 0165-0327
VL - 13
SP - 1
EP - 8
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1
ER -
