Dendritic RNA Transport: Dynamic Spatio-Temporal Control of Neuronal Gene Expression

J. B. Dictenberg, Robert H. Singer

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The localization and translation of messenger RNA (mRNA) within dendrites is a specialized form of gene expression which enables neurons to locally manage information flow and provides a mechanism for the spatiotemporal regulation of structural synapse plasticity that contributes to learning and memory. The delivery of mRNA from the nucleus into dendrites involves complex formation between. cis-acting elements and numerous. trans-acting proteins, which display dynamic movements and play essential roles in the maintenance of several forms of synaptic plasticity in the mammalian brain. The diverse composition of these posttranscriptional operons is presented in the context of activity-regulated dendritic mRNA transport with regard to their role in synaptic plasticity and defects in their regulation that result in neuronal disease. An example of the analysis of rapid dendritic transport in living hippocampal neurons is presented that shows calcium/calmodulin-dependent protein kinase II (CaMKII)-alpha mRNA movements at rates tenfold greater than previously estimated using improved imaging techniques.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages437-444
Number of pages8
ISBN (Print)9780080450469
DOIs
StatePublished - 2010

Fingerprint

RNA Transport
Gene Expression
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Messenger RNA
Neuronal Plasticity
Dendrites
Neurons
Calcium-Calmodulin-Dependent Protein Kinases
Operon
Synapses
Maintenance
Learning
Brain
Proteins

Keywords

  • CaMKII-alphaCytoskeletonDendritic mRNAGene expressionLive imagingMicrotubule transportNeuronal diseaseRNA-binding proteinSynaptic plasticityZipcode

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dendritic RNA Transport : Dynamic Spatio-Temporal Control of Neuronal Gene Expression. / Dictenberg, J. B.; Singer, Robert H.

Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 437-444.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dictenberg, J. B. ; Singer, Robert H. / Dendritic RNA Transport : Dynamic Spatio-Temporal Control of Neuronal Gene Expression. Encyclopedia of Neuroscience. Elsevier Ltd, 2010. pp. 437-444
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