TY - JOUR
T1 - Dendritic cell interactions with Histoplasma and Paracoccidioides
AU - Thind, Sharanjeet K.
AU - Taborda, Carlos P.
AU - Nosanchuk, Joshua D.
N1 - Publisher Copyright:
© 2015 Taylor & Francis Group, LLC.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Fungi are among the most common microbes encountered by humans. More than 100, 000 fungal species have been described in the environment to date, however only a few species cause disease in humans. Fungal infections are of particular importance to immunocompromised hosts in whom disease is often more severe, especially in those with impaired cell-mediated immunity such as individuals with HIV infection, hematologic malignancies, or those receiving TNF-α inhibitors. Nevertheless, environmental disturbances through natural processes or as a consequence of deforestation or construction can expose immunologically competent people to a large number of fungal spores resulting in asymptomatic acquisition to life-threatening disease. In recent decades, the significance of the innate immune system and more importantly the role of dendritic cells (DC) have been found to play a fundamental role in the resolution of fungal infections, such as in dimorphic fungi like Histoplasma and Paracoccidioides. In this review article the general role of DCs will be illustrated as the bridge between the innate and adaptiv.immune systems, as well as their specific interactions with these 2 dimorphic fungi.
AB - Fungi are among the most common microbes encountered by humans. More than 100, 000 fungal species have been described in the environment to date, however only a few species cause disease in humans. Fungal infections are of particular importance to immunocompromised hosts in whom disease is often more severe, especially in those with impaired cell-mediated immunity such as individuals with HIV infection, hematologic malignancies, or those receiving TNF-α inhibitors. Nevertheless, environmental disturbances through natural processes or as a consequence of deforestation or construction can expose immunologically competent people to a large number of fungal spores resulting in asymptomatic acquisition to life-threatening disease. In recent decades, the significance of the innate immune system and more importantly the role of dendritic cells (DC) have been found to play a fundamental role in the resolution of fungal infections, such as in dimorphic fungi like Histoplasma and Paracoccidioides. In this review article the general role of DCs will be illustrated as the bridge between the innate and adaptiv.immune systems, as well as their specific interactions with these 2 dimorphic fungi.
KW - Dendritic cell
KW - Histoplasma
KW - Immunoresponse
KW - Paracoccidioides
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U2 - 10.4161/21505594.2014.965586
DO - 10.4161/21505594.2014.965586
M3 - Review article
C2 - 25933034
AN - SCOPUS:84944449360
SN - 2150-5594
VL - 6
SP - 424
EP - 432
JO - Virulence
JF - Virulence
IS - 5
ER -