Demonstration of neurofibrillary tangles in the indusium griseum and of axonal disturbances in sagittal sulcal lesions of the corpus callosum: An immunohistochemical investigation

Takahiko Umahara, Asao Hirano, Noriyuki Shibata, Shinsuke Kato, Toru Kawanami

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This is an immunohistochemical investigation of the indusium griseum (supracommissural hippocampus) of the brains of control subjects and patients with Alzheimer's disease (AD). Our assays revealed the presence of fine deposits of synaptophysin-positive dots in the neuropil and around neurons in the indusium griseum of control subjects. By using an antibody to Alzheimer neurofibrillary tangles (NFT) we identified NFT and neuropil thread-like structures in the indusium griseum of AD patients; no β-amyloid protein-containing senile plaques were seen. To our knowledge, this is the first documentation of the occurrence of NFT in the indusium griseum. We also performed immunohistochemical assays on anterior sagittal sulcal lesions of the corpus callosum (ASSLCC), also known as surface lesions of the corpus callosum. These studies revealed a uniformly increased expression of the 200 kDa phosphorylated neurofilament protein by the axons in the pale myelin areas around the zonal depressions caused by the mechanical pressure of the anterior pericallosal artery. By contrast, immunoreactivity with an antibody to glial fibrillary acidic protein was either unchanged or reduced in the ASSLCC.

Original languageEnglish (US)
Pages (from-to)10-14
Number of pages5
JournalNeuropathology
Volume16
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Neurofibrillary Tangles
Corpus Callosum
Alzheimer Disease
Neuropil Threads
Neurofilament Proteins
Amyloidogenic Proteins
Synaptophysin
Neuropil
Antibodies
Glial Fibrillary Acidic Protein
Amyloid Plaques
Myelin Sheath
Documentation
Axons
Hippocampus
Arteries
Depression
Neurons
Pressure
Limbic Lobe

Keywords

  • Alzheimer's disease
  • Corpus callosum
  • Immunohistochemistry
  • Indusium griseum
  • Neurofibrillary tangles

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Demonstration of neurofibrillary tangles in the indusium griseum and of axonal disturbances in sagittal sulcal lesions of the corpus callosum : An immunohistochemical investigation. / Umahara, Takahiko; Hirano, Asao; Shibata, Noriyuki; Kato, Shinsuke; Kawanami, Toru.

In: Neuropathology, Vol. 16, No. 1, 1996, p. 10-14.

Research output: Contribution to journalArticle

Umahara, Takahiko ; Hirano, Asao ; Shibata, Noriyuki ; Kato, Shinsuke ; Kawanami, Toru. / Demonstration of neurofibrillary tangles in the indusium griseum and of axonal disturbances in sagittal sulcal lesions of the corpus callosum : An immunohistochemical investigation. In: Neuropathology. 1996 ; Vol. 16, No. 1. pp. 10-14.
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