Delayed wave of c-Fos expression in the dorsal hippocampus involved specifically in persistence of long-term memory storage

Cynthia Katche, Pedro Bekinschteina, Leandro Slipczuk, Andrea Goldin, Ivan A. Izquierdo, Martin Cammarota, Jorge H. Medina

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

Memory formation is a temporally graded process during which transcription and translation steps are required in the first hours after acquisition. Although persistence is a key characteristic of memory storage, its mechanisms are scarcely characterized. Here, we show that long-lasting but not short-lived inhibitory avoidance long-term memory is associated with a delayed expression of c-Fos in the hippocampus. Importantly, this late wave of c-Fos is necessary for maintenance of inhibitory avoidance long-term storage. Moreover, inhibition of transcription in the dorsal hippocampus 24 h after training hinders persistence but not formation of long-term storage. These findings indicate that a delayed phase of transcription is essential for maintenance of a hippocampus-dependent memory trace. Our results support the hypothesis that recurrent rounds of consolidation-like events take place late after learning in the dorsal hippocampus to maintain memories.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number1
DOIs
StatePublished - 2010

Keywords

  • Alpha-amanitin
  • BDNF
  • Gene expression
  • Inhibitory avoidance
  • Noradrenaline

ASJC Scopus subject areas

  • General

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