Delayed hematopoietic development in osteopetrotic (op/op) mice

Susan K. Begg, John M. Radley, Jeffrey W. Pollard, Orin T. Chisholm, E. Richard Stanley, Ivan Bertoncello

Research output: Contribution to journalArticle

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Abstract

Changes in structure, cellularity, hematopoietic progenitor cell and macrophage content, and osteoclast activity were investigated in the hematopoietic organs of the colony-stimulating factor 1(CSF-1)-less osteopetrotic (op/op) mouse. The data indicated that op/op mice undergo an age-related hematopoietic recovery and resolution of osteopetrosis, suggesting that the hematopoietic system has the capacity to use alternative mechanisms to compensate for the absence of an important multifunctional growth factor, CSF-1. In young animals, op/op femurs were heavily infiltrated with bone, and marrow cellularity was significantly reduced. After 6 wk of age, there was an increase in the marrow space available for hematopoiesis. The femoral cavity of op/op mice progressively enlarged, and by 22 wk of age its appearance and marrow cellularity was comparable to that of controls. The percentage of op/op mononuclear phagocytes, defined by F4/80 antigen expression, progressively increased to normal levels by 35 wk of age. There was no difference in the incidence of both primitive and mononuclear phagocyte-committed, CSF-1-responsive progenitor cells in op/op marrow, but their femoral content was significantly reduced in young mice. During the period of reduced hematopoiesis in the marrow of young op/op mice, splenic hematopoietic activity was elevated. This mutant mouse represents a system for the study of the CSF-1-independent regulatory mechanisms involved in hematopoietic regulation.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalJournal of Experimental Medicine
Volume177
Issue number1
StatePublished - Jan 1 1993

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Macrophage Colony-Stimulating Factor
Bone Marrow
Hematopoiesis
Phagocytes
Thigh
Osteopetrosis
Hematopoietic System
Osteoclasts
Hematopoietic Stem Cells
Femur
Intercellular Signaling Peptides and Proteins
Stem Cells
Macrophages
Incidence

ASJC Scopus subject areas

  • Immunology

Cite this

Begg, S. K., Radley, J. M., Pollard, J. W., Chisholm, O. T., Stanley, E. R., & Bertoncello, I. (1993). Delayed hematopoietic development in osteopetrotic (op/op) mice. Journal of Experimental Medicine, 177(1), 237-242.

Delayed hematopoietic development in osteopetrotic (op/op) mice. / Begg, Susan K.; Radley, John M.; Pollard, Jeffrey W.; Chisholm, Orin T.; Stanley, E. Richard; Bertoncello, Ivan.

In: Journal of Experimental Medicine, Vol. 177, No. 1, 01.01.1993, p. 237-242.

Research output: Contribution to journalArticle

Begg, SK, Radley, JM, Pollard, JW, Chisholm, OT, Stanley, ER & Bertoncello, I 1993, 'Delayed hematopoietic development in osteopetrotic (op/op) mice', Journal of Experimental Medicine, vol. 177, no. 1, pp. 237-242.
Begg SK, Radley JM, Pollard JW, Chisholm OT, Stanley ER, Bertoncello I. Delayed hematopoietic development in osteopetrotic (op/op) mice. Journal of Experimental Medicine. 1993 Jan 1;177(1):237-242.
Begg, Susan K. ; Radley, John M. ; Pollard, Jeffrey W. ; Chisholm, Orin T. ; Stanley, E. Richard ; Bertoncello, Ivan. / Delayed hematopoietic development in osteopetrotic (op/op) mice. In: Journal of Experimental Medicine. 1993 ; Vol. 177, No. 1. pp. 237-242.
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