Delayed awakening from general anaesthesia in a patient with Hunter syndrome

Alan Kreidstein, Martin R. Boorin, Paul Crespi, Philip Lebowitz, Samuel Barst

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Hunter syndrome is one of a heterogeneous group of recessively inherited mucopolysaccharide storage diseases (MPS) with similar biochemical defects manifested by impairments in muco-polysaccharide catabolism with variable but progressive clinical courses. Abnormal accumulation and deposition of mucopoly-saccharides in the tissues of several organs lead to numerous anatomical, musculoskeletal and neurological abnormalities which are known to complicate anaesthetic and airway management. Hunter syndrome has a wide variance of clinical phenotypes ranging from mild to severe. We present a patient having physical and neurological features consistent with a severe clinical presentation of Hunter syndrome (MPS, Type II). Following a seemingly uneventful intraoperative anaesthetic course including isoflurane, nitrous oxide and fentanyl (0.93 μg · kg-1), resumption of spontaneous ventilation and return to consciousness were delayed until intravenous naloxone (200 μg) was administered 100 min after the opioid administration. The cause of delayed recovery from anaesthesia in this patient is unknown.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalCanadian Journal of Anaesthesia
Volume41
Issue number5
DOIs
Publication statusPublished - May 1 1994

    Fingerprint

Keywords

  • anaesthesia: paediatric
  • analgesics: fentanyl
  • syndromes: mucopolysaccharidoses
  • ventilation: anaesthetics, effects of

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Kreidstein, A., Boorin, M. R., Crespi, P., Lebowitz, P., & Barst, S. (1994). Delayed awakening from general anaesthesia in a patient with Hunter syndrome. Canadian Journal of Anaesthesia, 41(5), 423-426. https://doi.org/10.1007/BF03009866