Defining the spectrum of international practice in pediatric epilepsy surgery patients

A. Simon Harvey, J. Helen Cross, Shlomo Shinnar, Gary W. Mathern

Research output: Contribution to journalArticle

268 Citations (Scopus)

Abstract

Purpose: The Pediatric Epilepsy Surgery Sub-commission of the International League Against Epilepsy conducted a survey to determine the frequency of epilepsy procedures and etiologies. Methods: Data were gathered from 20 programs in the United States, Europe, and Australia on 543 patients (<18 years) for calendar year 2004. Results: Age at seizure onset was 1 year or less in 46% of patients. Intracranial electrodes were used in 27% of patients. The most common final operation was lobar and focal resections of the frontal and temporal lobes (41%), followed by cerebral hemispherectomy (16%), vagus nerve stimulator (16%), and multilobar resections (13%). Multiple-subpial transections were uncommon procedures (0.6%). The most frequent etiologies were cortical dysplasia (42%), tumors (19%), and atrophic lesions and strokes (10%). Less common were vascular lesions (1.5%), Rasmussen encephalitis (3%), Sturge-Weber (3%), and operations for infantile spasms (4%), and Landau-Kleffner/ESES (<2%). Children <4 years generally presented with daily seizures from cortical dysplasia and underwent multilobar or hemispherectomy. Previous surgeries before 2004 were reported in 22%, and occurred more commonly in patients with tumors (40%), hypothalamic hamartomas (47%), and vascular lesions (67%). U.S. centers reported more vagus nerve stimulator procedures, operated more often on children with no or subtle MRI findings, and used intracranial electrodes and functional neuroimaging more frequently than programs in Europe and Australia. Conclusions: The results of this international survey show the feasibility of international collaborations in determining epilepsy etiologies and procedures in children, and suggest differences in clinical practice between regions of the world. These results can guide the design of future studies in producing guidelines for therapy-resistant pediatric epilepsy surgery patients.

Original languageEnglish (US)
Pages (from-to)146-155
Number of pages10
JournalEpilepsia
Volume49
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Epilepsy
Pediatrics
Hemispherectomy
Malformations of Cortical Development
Vagus Nerve
Blood Vessels
Electrodes
Seizures
Infantile Spasms
Functional Neuroimaging
Frontal Lobe
Encephalitis
Temporal Lobe
Age of Onset
Neoplasms
Stroke
Guidelines
Surveys and Questionnaires
Therapeutics

Keywords

  • Epileptic encephalopathy
  • Etiologies
  • FDG-PET
  • Ictal-SPECT
  • Intracarotid amobarbital procedure
  • MRI
  • Reoperation
  • Seizure syndrome
  • Tumor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Defining the spectrum of international practice in pediatric epilepsy surgery patients. / Harvey, A. Simon; Cross, J. Helen; Shinnar, Shlomo; Mathern, Gary W.

In: Epilepsia, Vol. 49, No. 1, 01.2008, p. 146-155.

Research output: Contribution to journalArticle

Harvey, A. Simon ; Cross, J. Helen ; Shinnar, Shlomo ; Mathern, Gary W. / Defining the spectrum of international practice in pediatric epilepsy surgery patients. In: Epilepsia. 2008 ; Vol. 49, No. 1. pp. 146-155.
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