Deficits in psychological well-being and quality-of-life in minor depression: Implications for DSM-V

Andrew A. Nierenberg, Mark Hyman Rapaport, Pamela J. Schettler, Robert H. Howland, Juliana A. Smith, Deidre Edwards, Trisha Schneider, David Mischoulon

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Objective: To examine deficits in psychological well-being (PWB) and quality-of-life (QOL) in minor depressive disorder (Min D). Method: Ninety-three subjects entering a treatment study for Min D were assessed using the QOL, Enjoyment and satisfaction questionnaire (Q-LES-Q), and the Psychological Well-Being Scale (PWBS). Scores were compared with major depressive disorder (MDD) and normative community samples. Results: Even though subjects had mild depressive severity, Q-LES-Q total scores for the Min D sample averaged nearly two standard deviations below the community norm. Almost 40% of Min D cases had Q-LES-Q scores in the lowest 1% of the population. Responses to most Q-LES-Q items were closer to subjects with MDD than to community norms. Mean standardized PWB scores were extremely low for subscales of Environmental Mastery and Self-Acceptance, low for Purpose in Life and Positive Relations with others, but within the normal range for Personal Growth and Autonomy. QOL and PWB measures had low correlations with depressive symptom severity, and scores were similar in the presence or absence of a prior history of MDD. Conclusions: Mild depressive symptoms with Min D are associated with major deficits in QOL and PWB measures of environmental mastery and poor self-acceptance. Our findings suggest that diminished QOL and PWB may be intrinsic cognitive aspects of Min D with or without a history of MDD. It may be unnecessary in the DSM IV-TR to exclude the diagnosis of Min D if a subject has had a past episode of MDD. • Minor depression exists along a continuum of depression. • Deficits in psychological well-being and quality-of-life in minor depression are severe. • No difference in these measures if minor depression existed with or without a history of major depression.

Original languageEnglish (US)
Pages (from-to)208-216
Number of pages9
JournalCNS Neuroscience and Therapeutics
Volume16
Issue number4
DOIs
StatePublished - Aug 2010

Keywords

  • Minor Depression
  • Psychological Well-Being
  • Quality of Life

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Physiology (medical)
  • Pharmacology (medical)

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