Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism

M. A. Levine, R. W. Downs, M. Singer, S. J. Marx, G. D. Aurbach, Allen M. Spiegel

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

The activity in two assay systems of guanine nucleotide regulatory protein was significantly lower in red cells from pseudohypoparathyroid patients compared to that of normal subjects. The results support the hypothesis that deficient activity of the guanine nucleotide regulatory protein is the molecular basis for hormone resistance in this inherited disorder.

Original languageEnglish (US)
Pages (from-to)1319-1324
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume94
Issue number4
DOIs
StatePublished - Jun 30 1980
Externally publishedYes

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Pseudohypoparathyroidism
GTP-Binding Proteins
Erythrocytes
Assays
Cells
Hormones

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism. / Levine, M. A.; Downs, R. W.; Singer, M.; Marx, S. J.; Aurbach, G. D.; Spiegel, Allen M.

In: Biochemical and Biophysical Research Communications, Vol. 94, No. 4, 30.06.1980, p. 1319-1324.

Research output: Contribution to journalArticle

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