TY - JOUR
T1 - Defective humoral immunity in pediatric acquired immune deficiency syndrome
AU - Bernstein, Larry J.
AU - Ochs, Hans D.
AU - Wedgwood, Ralph J.
AU - Rubinstein, Arye
N1 - Funding Information:
From the Division of Clinical Allergy and Immunology, Departments of Pediatrics, Microbiology, and Immunology, the Albert Einstein College of Medicine, Bronx, and the Division of Immunology and Rheumatology, Department of Pediatrics, University of Washington School of Medicine, Seattle. Supported by. Grants 1 UO1 AI 20671-01 and A1 07073from the National Institutes of Health, Grants 371 and 6-273 from the March of Dimes, and a grant from Cutter Laboratories, Inc. Submitted for publication Jan. 30, 1985; accepted March 22, 1985. Reprint requests." Dr. Larry J. Bernstein, Rm. 426, Forchheimer Bldg, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx. NY 10461.
PY - 1985/9
Y1 - 1985/9
N2 - Specific antibody production was assessed in six young children with the acquired immune deficiency syndrome (AIDS). All patients were immunized with bacteriophage X 174, a T cell-dependent neoantigen. In addition, antibody responses to pneumococcal vaccine and tetanus toxoid, lymphocyte responses to mitogens, and serum immunoglobulin levels were determined. Polyclonal hypergammaglobulinemia was documented in three patients. Responses to bacteriophage X 174 were abnormal in all patients: primary responses were blunted, secondary responses were markedly decreased, and the class switch (IgM-IgG) was absent in five of six patients. Antibody formation to pneumococcal vaccine and tetanus toxoid was also diminished. Lymphocyte mitogenic responses to phytohemagglutinin, concanavalin A, pokeweed mitogen, and staphylococcal Cowan A were generally decreased. These findings confirm that pediatric patients with AIDS have significant abnormalities in humoral immunity. Dysfunction of both T cells and B cells plays a role in the resultant poor specific antibody production.
AB - Specific antibody production was assessed in six young children with the acquired immune deficiency syndrome (AIDS). All patients were immunized with bacteriophage X 174, a T cell-dependent neoantigen. In addition, antibody responses to pneumococcal vaccine and tetanus toxoid, lymphocyte responses to mitogens, and serum immunoglobulin levels were determined. Polyclonal hypergammaglobulinemia was documented in three patients. Responses to bacteriophage X 174 were abnormal in all patients: primary responses were blunted, secondary responses were markedly decreased, and the class switch (IgM-IgG) was absent in five of six patients. Antibody formation to pneumococcal vaccine and tetanus toxoid was also diminished. Lymphocyte mitogenic responses to phytohemagglutinin, concanavalin A, pokeweed mitogen, and staphylococcal Cowan A were generally decreased. These findings confirm that pediatric patients with AIDS have significant abnormalities in humoral immunity. Dysfunction of both T cells and B cells plays a role in the resultant poor specific antibody production.
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U2 - 10.1016/S0022-3476(85)80505-9
DO - 10.1016/S0022-3476(85)80505-9
M3 - Article
C2 - 4032129
AN - SCOPUS:0021926764
SN - 0022-3476
VL - 107
SP - 352
EP - 357
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 3
ER -
