Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe

Grigory S. Filonov, Arie Krumholz, Jun Xia, Junjie Yao, Lihong V. Wang, Vladislav V. Verkhusha

Research output: Contribution to journalArticle

126 Scopus citations

Abstract

Skin-deep: The combination of a near-infrared fluorescent protein (iRFP) and deep-tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.

Original languageEnglish (US)
Pages (from-to)1448-1451
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number6
DOIs
StatePublished - Feb 6 2012

Keywords

  • absorption
  • cancer
  • fluorescent proteins
  • imaging agents
  • photoacoustic imaging

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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