Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function

A. S. Widge, S. Zorowitz, I. Basu, A. C. Paulk, S. S. Cash, Emad N. Eskandar, T. Deckersbach, E. K. Miller, D. D. Dougherty

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Deep brain stimulation (DBS) is a circuit-oriented treatment for mental disorders. Unfortunately, even well-conducted psychiatric DBS clinical trials have yielded inconsistent symptom relief, in part because DBS’ mechanism(s) of action are unclear. One clue to those mechanisms may lie in the efficacy of ventral internal capsule/ventral striatum (VCVS) DBS in both major depression (MDD) and obsessive-compulsive disorder (OCD). MDD and OCD both involve deficits in cognitive control. Cognitive control depends on prefrontal cortex (PFC) regions that project into the VCVS. Here, we show that VCVS DBS’ effect is explained in part by enhancement of PFC-driven cognitive control. DBS improves human subjects’ performance on a cognitive control task and increases theta (5–8Hz) oscillations in both medial and lateral PFC. The theta increase predicts subjects’ clinical outcomes. Our results suggest a possible mechanistic approach to DBS therapy, based on tuning stimulation to optimize these neurophysiologic phenomena.

Original languageEnglish (US)
Article number1536
JournalNature Communications
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

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Internal Capsule
Deep Brain Stimulation
cortexes
capsules
Prefrontal Cortex
stimulation
Capsules
brain
Brain
Obsessive-Compulsive Disorder
disorders
human performance
Mental Disorders
Psychiatry
Tuning
therapy
Clinical Trials
Depression
tuning
Networks (circuits)

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function. / Widge, A. S.; Zorowitz, S.; Basu, I.; Paulk, A. C.; Cash, S. S.; Eskandar, Emad N.; Deckersbach, T.; Miller, E. K.; Dougherty, D. D.

In: Nature Communications, Vol. 10, No. 1, 1536, 01.12.2019.

Research output: Contribution to journalArticle

Widge, AS, Zorowitz, S, Basu, I, Paulk, AC, Cash, SS, Eskandar, EN, Deckersbach, T, Miller, EK & Dougherty, DD 2019, 'Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function', Nature Communications, vol. 10, no. 1, 1536. https://doi.org/10.1038/s41467-019-09557-4
Widge, A. S. ; Zorowitz, S. ; Basu, I. ; Paulk, A. C. ; Cash, S. S. ; Eskandar, Emad N. ; Deckersbach, T. ; Miller, E. K. ; Dougherty, D. D. / Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function. In: Nature Communications. 2019 ; Vol. 10, No. 1.
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