Deep brain stimulation for obsessive-compulsive disorder: Past, present, and future

Matthew K. Mian, Michael Campos, Sameer A. Sheth, Emad N. Eskandar

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Obsessive-compulsive disorder (OCD) is a psychiatric illness that can lead to chronic functional impairment. Some patients with severe, chronic OCD have been treated with ablative neurosurgical techniques over the past 4 decades. More recently, deep brain stimulation (DBS) has been investigated as a therapy for refractory OCD, and the procedure was granted a limited humanitarian device exemption by the FDA in 2009. In this article, the authors review the development of DBS for OCD, describe the current understanding of the pathophysiological mechanisms of the disorder and how the underlying neural circuits might be modulated by DBS, and discuss the clinical studies that provide evidence for the use of this evolving therapy. The authors conclude with suggestions for how a combined basic science and translational research approach could drive the understanding of the neural mechanisms underlying OCD as well as the clinical effectiveness of DBS in the setting of recalcitrant disease.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalNeurosurgical Focus
Volume29
Issue number2
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

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Deep Brain Stimulation
Obsessive-Compulsive Disorder
Compassionate Use Trials
Translational Medical Research
Psychiatry
Therapeutics

Keywords

  • Deep brain stimulation
  • Obsessive-compulsive disorder
  • Psychiatric neurosurgery
  • Subthalamic nucleus
  • Ventral striatum

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Deep brain stimulation for obsessive-compulsive disorder : Past, present, and future. / Mian, Matthew K.; Campos, Michael; Sheth, Sameer A.; Eskandar, Emad N.

In: Neurosurgical Focus, Vol. 29, No. 2, 01.08.2010, p. 1-9.

Research output: Contribution to journalArticle

Mian, Matthew K. ; Campos, Michael ; Sheth, Sameer A. ; Eskandar, Emad N. / Deep brain stimulation for obsessive-compulsive disorder : Past, present, and future. In: Neurosurgical Focus. 2010 ; Vol. 29, No. 2. pp. 1-9.
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