Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors

Gary J. Schwartz, Andrew Whitney, Chris Skoglund, Thomas W. Castonguay, Timothy H. Moran

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Adult Otsuka Long-Evans Tokushima fatty (OLETF) rats lack functional cholecystokinin A (CCK-A) receptors, are diabetic, hyperphagic, and obese, and have patterns of ingestion consistent with a satiety deficit secondary to CCK insensitivity. Because dietary fat potently stimulates CCK release, we examined how dietary fat modulates feeding in adult male OLETF rats and their lean [Long-Evans Tokushima (LETO)] controls. High-fat feeding produced sustained overconsumption of high-fat diet (30% corn oil in powdered chow) over a 3-wk period in OLETF but not LETO rats. We then assessed the ability of gastric gavage (5 ml, 1-2 kcal/ml x 15 s) or duodenal preloads (1 kcal/ml, 0.44 ml/min x 10 min) of liquid carbohydrate (glucose), protein (peptone), or fat (Intralipid) to suppress subsequent 30-min 12.5% glucose intake in both strains. In OLETF rats, gastric and duodenal fat preloads were significantly less effective in suppressing subsequent intake than were equicaloric peptone or glucose. These results demonstrate that OLETF rats fail to compensate for fat calories and suggest that their hyperphagia and obesity may stem from a reduced ability to process nutrient-elicited gastrointestinal satiety signals.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume277
Issue number4 46-4
StatePublished - Oct 1999
Externally publishedYes

Fingerprint

Inbred OLETF Rats
Cholecystokinin A Receptor
Dietary Fats
Fats
Peptones
Glucose
Stomach
Hyperphagia
Long Evans Rats
Corn Oil
High Fat Diet
Obesity
Eating
Carbohydrates
Food
Proteins

Keywords

  • Brain-gut communication
  • Energy homeostasis
  • Food intake
  • Non-insulin-dependent diabetes mellitus
  • Obesity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors. / Schwartz, Gary J.; Whitney, Andrew; Skoglund, Chris; Castonguay, Thomas W.; Moran, Timothy H.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 277, No. 4 46-4, 10.1999.

Research output: Contribution to journalArticle

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