Decreased platelet monoamine oxidase activity in female anorexia nervosa

M. Díaz-Marsá, J. L. Carrasco, E. Hollander, J. César, J. Saiz-Ruiz

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Objective: To study if platelet MAO activity, previously described as a serotonergic index, is modified in a sample of pure restrictive anorectic patients. Method: Twenty-five female patients with DSM-IV anorexia nervosa restricting type were studied and compared with 30 healthy female controls. Platelet MAO activity was measured by isotopic methods using C-14 benzylamine. Impulsive personality features were measured with specific rating scales and temperament studied with Cloninger's TCI. Results: Platelet MAO activity was significantly lower (4.3 + 2.7 nmol/h/108 platelets) in the anorectic patients than in the control group (6.7 + 2.8) (P< 0.01). Platelet MAO was inversely correlated with scores on impulsivity scales and positively correlated with the dimension 'persistence' of Cloninger's TCI. Conclusion: Platelet MAO activity is lowered in a group of patients with anorexia nervosa and might involve some dysfunction in the regulation of impulse control.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalActa Psychiatrica Scandinavica
Volume101
Issue number3
DOIs
StatePublished - Mar 4 2000
Externally publishedYes

Keywords

  • Anorexia nervosa
  • Impulsivity
  • Monoamineoxidase (MAO)
  • Personality
  • Psychobiology
  • Serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health

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