Decreased numbers of CD4+ naive and effector memory T cells, and CD8+ naïve T cells, are associated with trichloroethylene exposure

Howard D. Hosgood, Luoping Zhang, Xiaojiang Tang, Roel Vermeulen, Chuangyi Qiu, Min Shen, Martyn T. Smith, Yichen Ge, Zhiying Ji, Jun Xiong, Jian He, Boris Reiss, Songwang Liu, Yuxuan Xie, Weihong Guo, Noe Galvan, Laiyu Li, Zhenyue Hao, Nathaniel Rothman, Hanlin Huang & 1 others Qing Lan

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Trichloroethylene (TCE) is a volatile chlorinated organic compound that is commonly used as a solvent for lipophilic compounds. Although recognized as an animal carcinogen, TCE's carcinogenic potential in humans is still uncertain. We have carried out a cross-sectional study of 80 workers exposed to TCE and 96 unexposed controls matched on age and sex in Guangdong, China to study TCE's early biologic effects. We previously reported that the total lymphocyte count and each of the major lymphocyte subsets (i.e., CD4+ T cells, CD8+ T cells, natural killer cells, and B cells) were decreased in TCE-exposed workers compared to controls, suggesting a selective effect on lymphoid progenitors, and/or lymphocyte survival. To explore which T lymphocyte subsets are affected in the same study population, we investigated the effect of TCE exposure on the numbers of CD4+ naïve and memory T cells, CD8+ naïve and memory T cells, and regulatory T cells by FACS analysis. Linear regression of each subset was used to test for differences between exposed workers and controls adjusting for potential confounders. We observed that CD4+ and CD8+ naïve T cell counts were about 8% (p = 0.056) and 17% (p = 0.0002) lower, respectively, among exposed workers. CD4+ effector memory T cell counts were decreased by about 20% among TCE-exposed workers compared to controls (p = 0.001). The selective targeting of TCE on CD8+ naive and possibly CD4+ naive T cells, and CD4+ effector memory T cells, provide further insights into the immunosuppression-related response of human immune cells upon TCE exposure.

Original languageEnglish (US)
Article number00053
JournalFrontiers in Oncology
Volume1
Issue numberJAN
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Trichloroethylene
T-Lymphocytes
Cell Count
Volatile Organic Compounds
Lymphocyte Subsets
Lymphocyte Count
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Natural Killer Cells
Carcinogens
Immunosuppression
Linear Models
China
B-Lymphocytes
Cross-Sectional Studies
Lymphocytes

Keywords

  • CD4
  • CD8
  • Lymphocyte
  • Memory
  • Naïve
  • Trichloroethylene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Decreased numbers of CD4+ naive and effector memory T cells, and CD8+ naïve T cells, are associated with trichloroethylene exposure. / Hosgood, Howard D.; Zhang, Luoping; Tang, Xiaojiang; Vermeulen, Roel; Qiu, Chuangyi; Shen, Min; Smith, Martyn T.; Ge, Yichen; Ji, Zhiying; Xiong, Jun; He, Jian; Reiss, Boris; Liu, Songwang; Xie, Yuxuan; Guo, Weihong; Galvan, Noe; Li, Laiyu; Hao, Zhenyue; Rothman, Nathaniel; Huang, Hanlin; Lan, Qing.

In: Frontiers in Oncology, Vol. 1, No. JAN, 00053, 2012.

Research output: Contribution to journalArticle

Hosgood, HD, Zhang, L, Tang, X, Vermeulen, R, Qiu, C, Shen, M, Smith, MT, Ge, Y, Ji, Z, Xiong, J, He, J, Reiss, B, Liu, S, Xie, Y, Guo, W, Galvan, N, Li, L, Hao, Z, Rothman, N, Huang, H & Lan, Q 2012, 'Decreased numbers of CD4+ naive and effector memory T cells, and CD8+ naïve T cells, are associated with trichloroethylene exposure', Frontiers in Oncology, vol. 1, no. JAN, 00053. https://doi.org/10.3389/fonc.2011.00053
Hosgood, Howard D. ; Zhang, Luoping ; Tang, Xiaojiang ; Vermeulen, Roel ; Qiu, Chuangyi ; Shen, Min ; Smith, Martyn T. ; Ge, Yichen ; Ji, Zhiying ; Xiong, Jun ; He, Jian ; Reiss, Boris ; Liu, Songwang ; Xie, Yuxuan ; Guo, Weihong ; Galvan, Noe ; Li, Laiyu ; Hao, Zhenyue ; Rothman, Nathaniel ; Huang, Hanlin ; Lan, Qing. / Decreased numbers of CD4+ naive and effector memory T cells, and CD8+ naïve T cells, are associated with trichloroethylene exposure. In: Frontiers in Oncology. 2012 ; Vol. 1, No. JAN.
@article{c27997abcbfe4711b51bfe6af8d07425,
title = "Decreased numbers of CD4+ naive and effector memory T cells, and CD8+ na{\"i}ve T cells, are associated with trichloroethylene exposure",
abstract = "Trichloroethylene (TCE) is a volatile chlorinated organic compound that is commonly used as a solvent for lipophilic compounds. Although recognized as an animal carcinogen, TCE's carcinogenic potential in humans is still uncertain. We have carried out a cross-sectional study of 80 workers exposed to TCE and 96 unexposed controls matched on age and sex in Guangdong, China to study TCE's early biologic effects. We previously reported that the total lymphocyte count and each of the major lymphocyte subsets (i.e., CD4+ T cells, CD8+ T cells, natural killer cells, and B cells) were decreased in TCE-exposed workers compared to controls, suggesting a selective effect on lymphoid progenitors, and/or lymphocyte survival. To explore which T lymphocyte subsets are affected in the same study population, we investigated the effect of TCE exposure on the numbers of CD4+ na{\"i}ve and memory T cells, CD8+ na{\"i}ve and memory T cells, and regulatory T cells by FACS analysis. Linear regression of each subset was used to test for differences between exposed workers and controls adjusting for potential confounders. We observed that CD4+ and CD8+ na{\"i}ve T cell counts were about 8{\%} (p = 0.056) and 17{\%} (p = 0.0002) lower, respectively, among exposed workers. CD4+ effector memory T cell counts were decreased by about 20{\%} among TCE-exposed workers compared to controls (p = 0.001). The selective targeting of TCE on CD8+ naive and possibly CD4+ naive T cells, and CD4+ effector memory T cells, provide further insights into the immunosuppression-related response of human immune cells upon TCE exposure.",
keywords = "CD4, CD8, Lymphocyte, Memory, Na{\"i}ve, Trichloroethylene",
author = "Hosgood, {Howard D.} and Luoping Zhang and Xiaojiang Tang and Roel Vermeulen and Chuangyi Qiu and Min Shen and Smith, {Martyn T.} and Yichen Ge and Zhiying Ji and Jun Xiong and Jian He and Boris Reiss and Songwang Liu and Yuxuan Xie and Weihong Guo and Noe Galvan and Laiyu Li and Zhenyue Hao and Nathaniel Rothman and Hanlin Huang and Qing Lan",
year = "2012",
doi = "10.3389/fonc.2011.00053",
language = "English (US)",
volume = "1",
journal = "Frontiers in Oncology",
issn = "2234-943X",
publisher = "Frontiers Media S. A.",
number = "JAN",

}

TY - JOUR

T1 - Decreased numbers of CD4+ naive and effector memory T cells, and CD8+ naïve T cells, are associated with trichloroethylene exposure

AU - Hosgood, Howard D.

AU - Zhang, Luoping

AU - Tang, Xiaojiang

AU - Vermeulen, Roel

AU - Qiu, Chuangyi

AU - Shen, Min

AU - Smith, Martyn T.

AU - Ge, Yichen

AU - Ji, Zhiying

AU - Xiong, Jun

AU - He, Jian

AU - Reiss, Boris

AU - Liu, Songwang

AU - Xie, Yuxuan

AU - Guo, Weihong

AU - Galvan, Noe

AU - Li, Laiyu

AU - Hao, Zhenyue

AU - Rothman, Nathaniel

AU - Huang, Hanlin

AU - Lan, Qing

PY - 2012

Y1 - 2012

N2 - Trichloroethylene (TCE) is a volatile chlorinated organic compound that is commonly used as a solvent for lipophilic compounds. Although recognized as an animal carcinogen, TCE's carcinogenic potential in humans is still uncertain. We have carried out a cross-sectional study of 80 workers exposed to TCE and 96 unexposed controls matched on age and sex in Guangdong, China to study TCE's early biologic effects. We previously reported that the total lymphocyte count and each of the major lymphocyte subsets (i.e., CD4+ T cells, CD8+ T cells, natural killer cells, and B cells) were decreased in TCE-exposed workers compared to controls, suggesting a selective effect on lymphoid progenitors, and/or lymphocyte survival. To explore which T lymphocyte subsets are affected in the same study population, we investigated the effect of TCE exposure on the numbers of CD4+ naïve and memory T cells, CD8+ naïve and memory T cells, and regulatory T cells by FACS analysis. Linear regression of each subset was used to test for differences between exposed workers and controls adjusting for potential confounders. We observed that CD4+ and CD8+ naïve T cell counts were about 8% (p = 0.056) and 17% (p = 0.0002) lower, respectively, among exposed workers. CD4+ effector memory T cell counts were decreased by about 20% among TCE-exposed workers compared to controls (p = 0.001). The selective targeting of TCE on CD8+ naive and possibly CD4+ naive T cells, and CD4+ effector memory T cells, provide further insights into the immunosuppression-related response of human immune cells upon TCE exposure.

AB - Trichloroethylene (TCE) is a volatile chlorinated organic compound that is commonly used as a solvent for lipophilic compounds. Although recognized as an animal carcinogen, TCE's carcinogenic potential in humans is still uncertain. We have carried out a cross-sectional study of 80 workers exposed to TCE and 96 unexposed controls matched on age and sex in Guangdong, China to study TCE's early biologic effects. We previously reported that the total lymphocyte count and each of the major lymphocyte subsets (i.e., CD4+ T cells, CD8+ T cells, natural killer cells, and B cells) were decreased in TCE-exposed workers compared to controls, suggesting a selective effect on lymphoid progenitors, and/or lymphocyte survival. To explore which T lymphocyte subsets are affected in the same study population, we investigated the effect of TCE exposure on the numbers of CD4+ naïve and memory T cells, CD8+ naïve and memory T cells, and regulatory T cells by FACS analysis. Linear regression of each subset was used to test for differences between exposed workers and controls adjusting for potential confounders. We observed that CD4+ and CD8+ naïve T cell counts were about 8% (p = 0.056) and 17% (p = 0.0002) lower, respectively, among exposed workers. CD4+ effector memory T cell counts were decreased by about 20% among TCE-exposed workers compared to controls (p = 0.001). The selective targeting of TCE on CD8+ naive and possibly CD4+ naive T cells, and CD4+ effector memory T cells, provide further insights into the immunosuppression-related response of human immune cells upon TCE exposure.

KW - CD4

KW - CD8

KW - Lymphocyte

KW - Memory

KW - Naïve

KW - Trichloroethylene

UR - http://www.scopus.com/inward/record.url?scp=84874619924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874619924&partnerID=8YFLogxK

U2 - 10.3389/fonc.2011.00053

DO - 10.3389/fonc.2011.00053

M3 - Article

VL - 1

JO - Frontiers in Oncology

JF - Frontiers in Oncology

SN - 2234-943X

IS - JAN

M1 - 00053

ER -