Decreased intercellular coupling after prolonged rapid stimulation in rabbit atrial muscle

J. Bredikis, F. Bukauskas, R. Veteikis

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Driving rabbit atrial trabeculae at a rapid rate for 15 minutes resulted in a decrease in the space constant for electrotonic decay from an average of 670 to 400 μm. Input resistance, R, as measured by use of a double-barrelled microelectrode, increased from a mean value of 380 kOhms to one of 600 kOhms. The time to return to control values after the end of rapid driving was 20-60 minutes. Similar effects of rapid driving were observed in the presence of atropine, propranolol, and atropine plus propranolol and phentolamine. According to the theory of current spread in a three-dimensional syncytium, a rise of input resistance should be interpreted mainly as an increase of cell-to-cell resistance. We advance the hypothesis that, when driven at their maximal possible rate (or when fibrillating), cardiac cells gain Na+ and Ca2+, and that this results in partial but reversible uncoupling.

Original languageEnglish (US)
Pages (from-to)815-820
Number of pages6
JournalCirculation Research
Volume49
Issue number3
StatePublished - 1981
Externally publishedYes

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Rabbits
Atropine
Propranolol
Muscles
Phentolamine
Microelectrodes
Giant Cells

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Decreased intercellular coupling after prolonged rapid stimulation in rabbit atrial muscle. / Bredikis, J.; Bukauskas, F.; Veteikis, R.

In: Circulation Research, Vol. 49, No. 3, 1981, p. 815-820.

Research output: Contribution to journalArticle

Bredikis, J, Bukauskas, F & Veteikis, R 1981, 'Decreased intercellular coupling after prolonged rapid stimulation in rabbit atrial muscle', Circulation Research, vol. 49, no. 3, pp. 815-820.
Bredikis, J. ; Bukauskas, F. ; Veteikis, R. / Decreased intercellular coupling after prolonged rapid stimulation in rabbit atrial muscle. In: Circulation Research. 1981 ; Vol. 49, No. 3. pp. 815-820.
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