Decreased insulin sensitivity and impaired fibrinolytic activity in type 2 diabetes patients and nondiabetics with ischemic stroke

Aleksandra Jotic, Tanja Milicic, Nadezda Covickovic Sternic, Vladimir S. Kostic, Katarina Lalic, Veljko Jeremic, Milija Mijajlovic, Ljiljana Lukic, Natasa Rajkovic, Milorad Civcic, Marija Macesic, Jelena P. Seferovic, Jelena Stanarcic, Sandra Aleksic, Nebojsa M. Lalic

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We analyzed (a) insulin sensitivity (IS), (b) plasma insulin (PI), and (c) plasminogen activator inhibitor-1 (PAI-1) in type 2 diabetes (T2D) patients with (group A) and without (group B) atherothrombotic ischemic stroke (ATIS), nondiabetics with ATIS (group C), and healthy controls (group D). IS was determined by minimal model (Si). Si was lower in A versus B (1.18 ± 0.67 versus 2.82 ± 0.61 min-1/mU/L × 104; P < 0.001) and in C versus D (3.18 ± 0.93 versus 6.13 ± 1.69 min-1/mU/L × 104; P < 0.001). PI and PAI-1 were higher in A versus B (PI: 19.61 ± 4.08 versus 14.91 ± 1.66 mU/L; P < 0.001, PAI-1: 7.75 ± 1.04 versus 4.57 ± 0.72 mU/L; P < 0.001) and in C versus D (PI: 15.14 ± 2.20 versus 7.58 ± 2.05 mU/L; P < 0.001, PAI-1: 4.78 ± 0.98 versus 3.49 ± 1.04 mU/L; P < 0.001). Si correlated with PAI-1 in T2D patients and nondiabetics, albeit stronger in T2D. Binary logistic regression identified insulin, PAI-1, and Si as independent predictors for ATIS in T2D patients and nondiabetics. The results imply that insulin resistance and fasting hyperinsulinemia might exert their atherogenic impact through the impaired fibrinolysis.

Original languageEnglish (US)
Article number934791
JournalInternational Journal of Endocrinology
Volume2015
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

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    Jotic, A., Milicic, T., Covickovic Sternic, N., Kostic, V. S., Lalic, K., Jeremic, V., Mijajlovic, M., Lukic, L., Rajkovic, N., Civcic, M., Macesic, M., Seferovic, J. P., Stanarcic, J., Aleksic, S., & Lalic, N. M. (2015). Decreased insulin sensitivity and impaired fibrinolytic activity in type 2 diabetes patients and nondiabetics with ischemic stroke. International Journal of Endocrinology, 2015, [934791]. https://doi.org/10.1155/2015/934791