Decreased insulin sensitivity and impaired fibrinolytic activity in type 2 diabetes patients and nondiabetics with ischemic stroke

Aleksandra Jotic, Tanja Milicic, Nadezda Covickovic Sternic, Vladimir S. Kostic, Katarina Lalic, Veljko Jeremic, Milija Mijajlovic, Ljiljana Lukic, Natasa Rajkovic, Milorad Civcic, Marija Macesic, Jelena P. Seferovic, Jelena Stanarcic, Sandra Aleksic, Nebojsa M. Lalic

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We analyzed (a) insulin sensitivity (IS), (b) plasma insulin (PI), and (c) plasminogen activator inhibitor-1 (PAI-1) in type 2 diabetes (T2D) patients with (group A) and without (group B) atherothrombotic ischemic stroke (ATIS), nondiabetics with ATIS (group C), and healthy controls (group D). IS was determined by minimal model (Si). Si was lower in A versus B (1.18 ± 0.67 versus 2.82 ± 0.61 min-1/mU/L × 104; P < 0.001) and in C versus D (3.18 ± 0.93 versus 6.13 ± 1.69 min-1/mU/L × 104; P < 0.001). PI and PAI-1 were higher in A versus B (PI: 19.61 ± 4.08 versus 14.91 ± 1.66 mU/L; P < 0.001, PAI-1: 7.75 ± 1.04 versus 4.57 ± 0.72 mU/L; P < 0.001) and in C versus D (PI: 15.14 ± 2.20 versus 7.58 ± 2.05 mU/L; P < 0.001, PAI-1: 4.78 ± 0.98 versus 3.49 ± 1.04 mU/L; P < 0.001). Si correlated with PAI-1 in T2D patients and nondiabetics, albeit stronger in T2D. Binary logistic regression identified insulin, PAI-1, and Si as independent predictors for ATIS in T2D patients and nondiabetics. The results imply that insulin resistance and fasting hyperinsulinemia might exert their atherogenic impact through the impaired fibrinolysis.

Original languageEnglish (US)
Article number934791
JournalInternational Journal of Endocrinology
Volume2015
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Plasminogen Activator Inhibitor 1
Type 2 Diabetes Mellitus
Insulin Resistance
Stroke
lysine clonixinate
Insulin
Hyperinsulinism
Fibrinolysis
Fasting
Logistic Models
Control Groups

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

Cite this

Decreased insulin sensitivity and impaired fibrinolytic activity in type 2 diabetes patients and nondiabetics with ischemic stroke. / Jotic, Aleksandra; Milicic, Tanja; Covickovic Sternic, Nadezda; Kostic, Vladimir S.; Lalic, Katarina; Jeremic, Veljko; Mijajlovic, Milija; Lukic, Ljiljana; Rajkovic, Natasa; Civcic, Milorad; Macesic, Marija; Seferovic, Jelena P.; Stanarcic, Jelena; Aleksic, Sandra; Lalic, Nebojsa M.

In: International Journal of Endocrinology, Vol. 2015, 934791, 01.01.2015.

Research output: Contribution to journalArticle

Jotic, A, Milicic, T, Covickovic Sternic, N, Kostic, VS, Lalic, K, Jeremic, V, Mijajlovic, M, Lukic, L, Rajkovic, N, Civcic, M, Macesic, M, Seferovic, JP, Stanarcic, J, Aleksic, S & Lalic, NM 2015, 'Decreased insulin sensitivity and impaired fibrinolytic activity in type 2 diabetes patients and nondiabetics with ischemic stroke', International Journal of Endocrinology, vol. 2015, 934791. https://doi.org/10.1155/2015/934791
Jotic, Aleksandra ; Milicic, Tanja ; Covickovic Sternic, Nadezda ; Kostic, Vladimir S. ; Lalic, Katarina ; Jeremic, Veljko ; Mijajlovic, Milija ; Lukic, Ljiljana ; Rajkovic, Natasa ; Civcic, Milorad ; Macesic, Marija ; Seferovic, Jelena P. ; Stanarcic, Jelena ; Aleksic, Sandra ; Lalic, Nebojsa M. / Decreased insulin sensitivity and impaired fibrinolytic activity in type 2 diabetes patients and nondiabetics with ischemic stroke. In: International Journal of Endocrinology. 2015 ; Vol. 2015.
@article{e7f49defb7c9460f8085be902fb43faa,
title = "Decreased insulin sensitivity and impaired fibrinolytic activity in type 2 diabetes patients and nondiabetics with ischemic stroke",
abstract = "We analyzed (a) insulin sensitivity (IS), (b) plasma insulin (PI), and (c) plasminogen activator inhibitor-1 (PAI-1) in type 2 diabetes (T2D) patients with (group A) and without (group B) atherothrombotic ischemic stroke (ATIS), nondiabetics with ATIS (group C), and healthy controls (group D). IS was determined by minimal model (Si). Si was lower in A versus B (1.18 ± 0.67 versus 2.82 ± 0.61 min-1/mU/L × 104; P < 0.001) and in C versus D (3.18 ± 0.93 versus 6.13 ± 1.69 min-1/mU/L × 104; P < 0.001). PI and PAI-1 were higher in A versus B (PI: 19.61 ± 4.08 versus 14.91 ± 1.66 mU/L; P < 0.001, PAI-1: 7.75 ± 1.04 versus 4.57 ± 0.72 mU/L; P < 0.001) and in C versus D (PI: 15.14 ± 2.20 versus 7.58 ± 2.05 mU/L; P < 0.001, PAI-1: 4.78 ± 0.98 versus 3.49 ± 1.04 mU/L; P < 0.001). Si correlated with PAI-1 in T2D patients and nondiabetics, albeit stronger in T2D. Binary logistic regression identified insulin, PAI-1, and Si as independent predictors for ATIS in T2D patients and nondiabetics. The results imply that insulin resistance and fasting hyperinsulinemia might exert their atherogenic impact through the impaired fibrinolysis.",
author = "Aleksandra Jotic and Tanja Milicic and {Covickovic Sternic}, Nadezda and Kostic, {Vladimir S.} and Katarina Lalic and Veljko Jeremic and Milija Mijajlovic and Ljiljana Lukic and Natasa Rajkovic and Milorad Civcic and Marija Macesic and Seferovic, {Jelena P.} and Jelena Stanarcic and Sandra Aleksic and Lalic, {Nebojsa M.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1155/2015/934791",
language = "English (US)",
volume = "2015",
journal = "International Journal of Endocrinology",
issn = "1687-8337",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Decreased insulin sensitivity and impaired fibrinolytic activity in type 2 diabetes patients and nondiabetics with ischemic stroke

AU - Jotic, Aleksandra

AU - Milicic, Tanja

AU - Covickovic Sternic, Nadezda

AU - Kostic, Vladimir S.

AU - Lalic, Katarina

AU - Jeremic, Veljko

AU - Mijajlovic, Milija

AU - Lukic, Ljiljana

AU - Rajkovic, Natasa

AU - Civcic, Milorad

AU - Macesic, Marija

AU - Seferovic, Jelena P.

AU - Stanarcic, Jelena

AU - Aleksic, Sandra

AU - Lalic, Nebojsa M.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We analyzed (a) insulin sensitivity (IS), (b) plasma insulin (PI), and (c) plasminogen activator inhibitor-1 (PAI-1) in type 2 diabetes (T2D) patients with (group A) and without (group B) atherothrombotic ischemic stroke (ATIS), nondiabetics with ATIS (group C), and healthy controls (group D). IS was determined by minimal model (Si). Si was lower in A versus B (1.18 ± 0.67 versus 2.82 ± 0.61 min-1/mU/L × 104; P < 0.001) and in C versus D (3.18 ± 0.93 versus 6.13 ± 1.69 min-1/mU/L × 104; P < 0.001). PI and PAI-1 were higher in A versus B (PI: 19.61 ± 4.08 versus 14.91 ± 1.66 mU/L; P < 0.001, PAI-1: 7.75 ± 1.04 versus 4.57 ± 0.72 mU/L; P < 0.001) and in C versus D (PI: 15.14 ± 2.20 versus 7.58 ± 2.05 mU/L; P < 0.001, PAI-1: 4.78 ± 0.98 versus 3.49 ± 1.04 mU/L; P < 0.001). Si correlated with PAI-1 in T2D patients and nondiabetics, albeit stronger in T2D. Binary logistic regression identified insulin, PAI-1, and Si as independent predictors for ATIS in T2D patients and nondiabetics. The results imply that insulin resistance and fasting hyperinsulinemia might exert their atherogenic impact through the impaired fibrinolysis.

AB - We analyzed (a) insulin sensitivity (IS), (b) plasma insulin (PI), and (c) plasminogen activator inhibitor-1 (PAI-1) in type 2 diabetes (T2D) patients with (group A) and without (group B) atherothrombotic ischemic stroke (ATIS), nondiabetics with ATIS (group C), and healthy controls (group D). IS was determined by minimal model (Si). Si was lower in A versus B (1.18 ± 0.67 versus 2.82 ± 0.61 min-1/mU/L × 104; P < 0.001) and in C versus D (3.18 ± 0.93 versus 6.13 ± 1.69 min-1/mU/L × 104; P < 0.001). PI and PAI-1 were higher in A versus B (PI: 19.61 ± 4.08 versus 14.91 ± 1.66 mU/L; P < 0.001, PAI-1: 7.75 ± 1.04 versus 4.57 ± 0.72 mU/L; P < 0.001) and in C versus D (PI: 15.14 ± 2.20 versus 7.58 ± 2.05 mU/L; P < 0.001, PAI-1: 4.78 ± 0.98 versus 3.49 ± 1.04 mU/L; P < 0.001). Si correlated with PAI-1 in T2D patients and nondiabetics, albeit stronger in T2D. Binary logistic regression identified insulin, PAI-1, and Si as independent predictors for ATIS in T2D patients and nondiabetics. The results imply that insulin resistance and fasting hyperinsulinemia might exert their atherogenic impact through the impaired fibrinolysis.

UR - http://www.scopus.com/inward/record.url?scp=84930634782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930634782&partnerID=8YFLogxK

U2 - 10.1155/2015/934791

DO - 10.1155/2015/934791

M3 - Article

AN - SCOPUS:84930634782

VL - 2015

JO - International Journal of Endocrinology

JF - International Journal of Endocrinology

SN - 1687-8337

M1 - 934791

ER -