Abstract
Decision making in both animals and humans is influenced by the anticipation of reward and/or punishment. Little is known about how reward and punishment interact in the context of decision making. The Avoidance–Reward Conflict (ARC) Task is a new paradigm that varies the degree of reward and the probability of punishment in a single paradigm that can be used in both non-human primates (NHPs) and humans. This study examined the behavioral pattern in the ARC task in both NHPs and humans. Two adult male NHPs (macaca mulatta) and 20 healthy human volunteers (12 females) participated in the ARC task. NHPs and humans perform similarly on the ARC task. With a high probability of punishment (an aversive air puff to the eye), both NHPs and humans are more likely to forgo reward if it is small or medium magnitude than when it is large. Both NHPs and humans perform similarly on the same behavioral task suggesting the reliability of animal models in predicting human behavior.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2509-2517 |
| Number of pages | 9 |
| Journal | Brain Structure and Function |
| Volume | 220 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 28 2015 |
| Externally published | Yes |
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Keywords
- Animal model
- Anxiety
- Bipolar disorder
- Obsessive–compulsive disorder (OCD)
ASJC Scopus subject areas
- Anatomy
- Neuroscience(all)
- Histology
Cite this
Decision making in avoidance–reward conflict : a paradigm for non-human primates and humans. / Sierra-Mercado, Demetrio; Deckersbach, Thilo; Arulpragasam, Amanda R.; Chou, Tina; Rodman, Alexandra M.; Duffy, Amanda; McDonald, Eric J.; Eckhardt, Christine A.; Corse, Andrew K.; Kaur, Navneet; Eskandar, Emad N.; Dougherty, Darin D.
In: Brain Structure and Function, Vol. 220, No. 5, 28.09.2015, p. 2509-2517.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decision making in avoidance–reward conflict
T2 - a paradigm for non-human primates and humans
AU - Sierra-Mercado, Demetrio
AU - Deckersbach, Thilo
AU - Arulpragasam, Amanda R.
AU - Chou, Tina
AU - Rodman, Alexandra M.
AU - Duffy, Amanda
AU - McDonald, Eric J.
AU - Eckhardt, Christine A.
AU - Corse, Andrew K.
AU - Kaur, Navneet
AU - Eskandar, Emad N.
AU - Dougherty, Darin D.
PY - 2015/9/28
Y1 - 2015/9/28
N2 - Decision making in both animals and humans is influenced by the anticipation of reward and/or punishment. Little is known about how reward and punishment interact in the context of decision making. The Avoidance–Reward Conflict (ARC) Task is a new paradigm that varies the degree of reward and the probability of punishment in a single paradigm that can be used in both non-human primates (NHPs) and humans. This study examined the behavioral pattern in the ARC task in both NHPs and humans. Two adult male NHPs (macaca mulatta) and 20 healthy human volunteers (12 females) participated in the ARC task. NHPs and humans perform similarly on the ARC task. With a high probability of punishment (an aversive air puff to the eye), both NHPs and humans are more likely to forgo reward if it is small or medium magnitude than when it is large. Both NHPs and humans perform similarly on the same behavioral task suggesting the reliability of animal models in predicting human behavior.
AB - Decision making in both animals and humans is influenced by the anticipation of reward and/or punishment. Little is known about how reward and punishment interact in the context of decision making. The Avoidance–Reward Conflict (ARC) Task is a new paradigm that varies the degree of reward and the probability of punishment in a single paradigm that can be used in both non-human primates (NHPs) and humans. This study examined the behavioral pattern in the ARC task in both NHPs and humans. Two adult male NHPs (macaca mulatta) and 20 healthy human volunteers (12 females) participated in the ARC task. NHPs and humans perform similarly on the ARC task. With a high probability of punishment (an aversive air puff to the eye), both NHPs and humans are more likely to forgo reward if it is small or medium magnitude than when it is large. Both NHPs and humans perform similarly on the same behavioral task suggesting the reliability of animal models in predicting human behavior.
KW - Animal model
KW - Anxiety
KW - Bipolar disorder
KW - Obsessive–compulsive disorder (OCD)
UR - http://www.scopus.com/inward/record.url?scp=84940575043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940575043&partnerID=8YFLogxK
U2 - 10.1007/s00429-014-0796-7
DO - 10.1007/s00429-014-0796-7
M3 - Article
C2 - 24969127
AN - SCOPUS:84940575043
VL - 220
SP - 2509
EP - 2517
JO - Referate und Beiträge zur Anatomie und Entwickelungsgeschichte
JF - Referate und Beiträge zur Anatomie und Entwickelungsgeschichte
SN - 0177-5154
IS - 5
ER -