Deciphering the transcriptional network of the dendritic cell lineage

Jennifer C. Miller, Brian D. Brown, Tal Shay, Emmanuel L. Gautier, Vladimir Jojic, Ariella Cohain, Gaurav Pandey, Marylene Leboeuf, Kutlu G. Elpek, Julie Helft, Daigo Hashimoto, Andrew Chow, Jeremy Price, Melanie Greter, Milena Bogunovic, Angelique Bellemare-Pelletier, Paul S. Frenette, Gwendalyn J. Randolph, Shannon J. Turley, Miriam Merad & 36 others Claudia Jakubzick, Adam J. Best, Jamie Knell, Ananda Goldrath, Daphne Koller, Nadia Cohen, Patrick Brennan, Michael Brenner, Aviv Regev, Anne Fletcher, Deepali Malhotra, Radu Jianu, David Laidlaw, Jim Collins, Kavitha Narayan, Katelyn Sylvia, Joonsoo Kang, Roi Gazit, Derrick J. Rossi, Francis Kim, Tata Nageswara Rao, Amy Wagers, Susan A. Shinton, Richard R. Hardy, Paul Monach, Natalie A. Bezman, Joseph C. Sun, Charlie C. Kim, Lewis L. Lanier, Tracy Heng, Taras Kreslavsky, Michio Painter, Jeffrey Ericson, Scott Davis, Diane Mathis, Christophe Benoist

Research output: Contribution to journalArticle

425 Citations (Scopus)

Abstract

Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs in vivo remains poorly understood. We made a comprehensive comparative analysis of CD8 +, CD103 +, CD11b + and plasmacytoid DC subsets, as well as macrophage DC precursors and common DC precursors, across the entire immune system. Here we characterized candidate transcriptional activators involved in the commitment of myeloid progenitor cells to the DC lineage and predicted regulators of DC functional diversity in tissues. We identified a molecular signature that distinguished tissue DCs from macrophages. We also identified a transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens.

Original languageEnglish (US)
Pages (from-to)888-899
Number of pages12
JournalNature Immunology
Volume13
Issue number9
DOIs
StatePublished - Sep 2012

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Gene Regulatory Networks
Cell Lineage
Dendritic Cells
Macrophages
Myeloid Progenitor Cells
Autoantigens
Immune System
Lymph Nodes

ASJC Scopus subject areas

  • Immunology

Cite this

Miller, J. C., Brown, B. D., Shay, T., Gautier, E. L., Jojic, V., Cohain, A., ... Benoist, C. (2012). Deciphering the transcriptional network of the dendritic cell lineage. Nature Immunology, 13(9), 888-899. https://doi.org/10.1038/ni.2370

Deciphering the transcriptional network of the dendritic cell lineage. / Miller, Jennifer C.; Brown, Brian D.; Shay, Tal; Gautier, Emmanuel L.; Jojic, Vladimir; Cohain, Ariella; Pandey, Gaurav; Leboeuf, Marylene; Elpek, Kutlu G.; Helft, Julie; Hashimoto, Daigo; Chow, Andrew; Price, Jeremy; Greter, Melanie; Bogunovic, Milena; Bellemare-Pelletier, Angelique; Frenette, Paul S.; Randolph, Gwendalyn J.; Turley, Shannon J.; Merad, Miriam; Jakubzick, Claudia; Best, Adam J.; Knell, Jamie; Goldrath, Ananda; Koller, Daphne; Cohen, Nadia; Brennan, Patrick; Brenner, Michael; Regev, Aviv; Fletcher, Anne; Malhotra, Deepali; Jianu, Radu; Laidlaw, David; Collins, Jim; Narayan, Kavitha; Sylvia, Katelyn; Kang, Joonsoo; Gazit, Roi; Rossi, Derrick J.; Kim, Francis; Rao, Tata Nageswara; Wagers, Amy; Shinton, Susan A.; Hardy, Richard R.; Monach, Paul; Bezman, Natalie A.; Sun, Joseph C.; Kim, Charlie C.; Lanier, Lewis L.; Heng, Tracy; Kreslavsky, Taras; Painter, Michio; Ericson, Jeffrey; Davis, Scott; Mathis, Diane; Benoist, Christophe.

In: Nature Immunology, Vol. 13, No. 9, 09.2012, p. 888-899.

Research output: Contribution to journalArticle

Miller, JC, Brown, BD, Shay, T, Gautier, EL, Jojic, V, Cohain, A, Pandey, G, Leboeuf, M, Elpek, KG, Helft, J, Hashimoto, D, Chow, A, Price, J, Greter, M, Bogunovic, M, Bellemare-Pelletier, A, Frenette, PS, Randolph, GJ, Turley, SJ, Merad, M, Jakubzick, C, Best, AJ, Knell, J, Goldrath, A, Koller, D, Cohen, N, Brennan, P, Brenner, M, Regev, A, Fletcher, A, Malhotra, D, Jianu, R, Laidlaw, D, Collins, J, Narayan, K, Sylvia, K, Kang, J, Gazit, R, Rossi, DJ, Kim, F, Rao, TN, Wagers, A, Shinton, SA, Hardy, RR, Monach, P, Bezman, NA, Sun, JC, Kim, CC, Lanier, LL, Heng, T, Kreslavsky, T, Painter, M, Ericson, J, Davis, S, Mathis, D & Benoist, C 2012, 'Deciphering the transcriptional network of the dendritic cell lineage', Nature Immunology, vol. 13, no. 9, pp. 888-899. https://doi.org/10.1038/ni.2370
Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, Cohain A et al. Deciphering the transcriptional network of the dendritic cell lineage. Nature Immunology. 2012 Sep;13(9):888-899. https://doi.org/10.1038/ni.2370
Miller, Jennifer C. ; Brown, Brian D. ; Shay, Tal ; Gautier, Emmanuel L. ; Jojic, Vladimir ; Cohain, Ariella ; Pandey, Gaurav ; Leboeuf, Marylene ; Elpek, Kutlu G. ; Helft, Julie ; Hashimoto, Daigo ; Chow, Andrew ; Price, Jeremy ; Greter, Melanie ; Bogunovic, Milena ; Bellemare-Pelletier, Angelique ; Frenette, Paul S. ; Randolph, Gwendalyn J. ; Turley, Shannon J. ; Merad, Miriam ; Jakubzick, Claudia ; Best, Adam J. ; Knell, Jamie ; Goldrath, Ananda ; Koller, Daphne ; Cohen, Nadia ; Brennan, Patrick ; Brenner, Michael ; Regev, Aviv ; Fletcher, Anne ; Malhotra, Deepali ; Jianu, Radu ; Laidlaw, David ; Collins, Jim ; Narayan, Kavitha ; Sylvia, Katelyn ; Kang, Joonsoo ; Gazit, Roi ; Rossi, Derrick J. ; Kim, Francis ; Rao, Tata Nageswara ; Wagers, Amy ; Shinton, Susan A. ; Hardy, Richard R. ; Monach, Paul ; Bezman, Natalie A. ; Sun, Joseph C. ; Kim, Charlie C. ; Lanier, Lewis L. ; Heng, Tracy ; Kreslavsky, Taras ; Painter, Michio ; Ericson, Jeffrey ; Davis, Scott ; Mathis, Diane ; Benoist, Christophe. / Deciphering the transcriptional network of the dendritic cell lineage. In: Nature Immunology. 2012 ; Vol. 13, No. 9. pp. 888-899.
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