Deciphering the message in protein sequences

Tolerance to amino acid substitutions

James U. Bowie, John F. Reidhaar-Olson, Wendell A. Lim, Robert T. Sauer

Research output: Contribution to journalArticle

383 Citations (Scopus)

Abstract

An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.

Original languageEnglish (US)
Pages (from-to)1306-1310
Number of pages5
JournalScience
Volume247
Issue number4948
StatePublished - Mar 16 1991
Externally publishedYes

Fingerprint

Amino Acid Substitution
Proteins
Amino Acid Sequence

ASJC Scopus subject areas

  • General

Cite this

Bowie, J. U., Reidhaar-Olson, J. F., Lim, W. A., & Sauer, R. T. (1991). Deciphering the message in protein sequences: Tolerance to amino acid substitutions. Science, 247(4948), 1306-1310.

Deciphering the message in protein sequences : Tolerance to amino acid substitutions. / Bowie, James U.; Reidhaar-Olson, John F.; Lim, Wendell A.; Sauer, Robert T.

In: Science, Vol. 247, No. 4948, 16.03.1991, p. 1306-1310.

Research output: Contribution to journalArticle

Bowie, JU, Reidhaar-Olson, JF, Lim, WA & Sauer, RT 1991, 'Deciphering the message in protein sequences: Tolerance to amino acid substitutions', Science, vol. 247, no. 4948, pp. 1306-1310.
Bowie JU, Reidhaar-Olson JF, Lim WA, Sauer RT. Deciphering the message in protein sequences: Tolerance to amino acid substitutions. Science. 1991 Mar 16;247(4948):1306-1310.
Bowie, James U. ; Reidhaar-Olson, John F. ; Lim, Wendell A. ; Sauer, Robert T. / Deciphering the message in protein sequences : Tolerance to amino acid substitutions. In: Science. 1991 ; Vol. 247, No. 4948. pp. 1306-1310.
@article{7f95c220b79842c196651d35721ec306,
title = "Deciphering the message in protein sequences: Tolerance to amino acid substitutions",
abstract = "An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.",
author = "Bowie, {James U.} and Reidhaar-Olson, {John F.} and Lim, {Wendell A.} and Sauer, {Robert T.}",
year = "1991",
month = "3",
day = "16",
language = "English (US)",
volume = "247",
pages = "1306--1310",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4948",

}

TY - JOUR

T1 - Deciphering the message in protein sequences

T2 - Tolerance to amino acid substitutions

AU - Bowie, James U.

AU - Reidhaar-Olson, John F.

AU - Lim, Wendell A.

AU - Sauer, Robert T.

PY - 1991/3/16

Y1 - 1991/3/16

N2 - An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.

AB - An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.

UR - http://www.scopus.com/inward/record.url?scp=0025363984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025363984&partnerID=8YFLogxK

M3 - Article

VL - 247

SP - 1306

EP - 1310

JO - Science

JF - Science

SN - 0036-8075

IS - 4948

ER -