Deciphering the message in protein sequences: Tolerance to amino acid substitutions

James U. Bowie; John F. Reidhaar-Olson; Wendell A. Lim; Robert T. Sauer

doi:10.1126/science.2315699

Deciphering the message in protein sequences: Tolerance to amino acid substitutions

James U. Bowie, John F. Reidhaar-Olson, Wendell A. Lim, Robert T. Sauer

Research output: Contribution to journal › Article › peer-review

445 Scopus citations

Abstract

An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.

Original language	English (US)
Pages (from-to)	1306-1310
Number of pages	5
Journal	Science
Volume	247
Issue number	4948
DOIs	https://doi.org/10.1126/science.2315699
State	Published - 1990
Externally published	Yes

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title = "Deciphering the message in protein sequences: Tolerance to amino acid substitutions",

abstract = "An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.",

author = "Bowie, {James U.} and Reidhaar-Olson, {John F.} and Lim, {Wendell A.} and Sauer, {Robert T.}",

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AU - Lim, Wendell A.

AU - Sauer, Robert T.

PY - 1990

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AB - An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.

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Deciphering the message in protein sequences: Tolerance to amino acid substitutions

Abstract

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