Deciphering the message in protein sequences: Tolerance to amino acid substitutions

James U. Bowie, John F. Reidhaar-Olson, Wendell A. Lim, Robert T. Sauer

Research output: Contribution to journalArticle

392 Scopus citations

Abstract

An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.

Original languageEnglish (US)
Pages (from-to)1306-1310
Number of pages5
JournalScience
Volume247
Issue number4948
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • General

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    Bowie, J. U., Reidhaar-Olson, J. F., Lim, W. A., & Sauer, R. T. (1990). Deciphering the message in protein sequences: Tolerance to amino acid substitutions. Science, 247(4948), 1306-1310. https://doi.org/10.1126/science.2315699